This paper investigates the optimal design of symmetric switching CMOS inverter using the Symbiotic Organisms Search (SOS) algorithm. SOS has been recently proposed as an effective evolutionary global optimization method that is inspired by the symbiotic interaction strategies between different organisms in an ecosystem. In SOS, the three common types of symbiotic relationships (mutualism, commensalism, and parasitism) are modeled using simple expressions, which are used to find the global minimum of the fitness function. Unlike other optimization methods, SOS has no parameters to be tuned, which makes it an attractive and easy-to-implement optimization method. Here, SOS is used to design a high speed symmetric switching CMOS inverter, which is considered the most fundamental logic gate. SOS results are compared to those obtained using several optimization methods, like particle swarm optimization (PSO), genetic algorithm (GA), differential evolution (DE), and other ones, available in the literature. It is shown that the SOS is a robust straight-forward evolutionary algorithm that can compete with other well-known advanced methods.