Optimal combinations for detection of prostate cancer: systematic sextant and laterally directed biopsies versus systematic sextant and color doppler-targeted biopsies

Kravchick, Sergey; Cytron, Shmuel; Peled, Ronit; London, Daniel A.; Sibi, Y.; Ben-Dor, David

doi:10.1016/j.urology.2003.09.034

Cited by 14 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We speculated that this might be caused by the high false-negative rate of prostate biopsy [2]. Over the last few years, lots of effort has been made on the optimization of initial prostate biopsy in clinical practice, and inherent within those optimizations is variation of the core number, location, labelling and processing for pathological evaluation [68–72]. To date, there is no consensus in this regard.…”

Section: Discussionmentioning

confidence: 99%

The value of diffusion-weighted imaging in the detection of prostate cancer: a meta-analysis

2014

View full text Add to dashboard Cite

ObjectivesTo evaluate the diagnostic performance of diffusion-weighted imaging (DWI) as a single non-invasive method in detecting prostate cancer (PCa) and to deduce its clinical utility.MethodsA systematic literature search was performed to identify relevant original studies. Quality of included studies was assessed by QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies). Data were extracted to calculate sensitivity and specificity as well as running the test of heterogeneity and threshold effect. The summary receiver operating characteristic (SROC) curve was drawn and area under SROC curve (AUC) served as a determination of the diagnostic performance of DWI for the detection of PCa.ResultsA total of 21 studies were included, with 27 subsets of data available for analysis. The pooled sensitivity and specificity with corresponding 95 % confidence interval (CI) were 0.62 (95 % CI 0.61–0.64) and 0.90 (95 % CI 0.89–0.90), respectively. Pooled positive likelihood ratio and negative likelihood ratio were 5.83 (95 % CI 4.61–7.37) and 0.30 (95 % CI 0.23–0.39), respectively. The AUC was 0.8991. Significant heterogeneity was observed. There was no notable publication bias.ConclusionsDWI is an informative MRI modality in detecting PCa and shows moderately high diagnostic accuracy. General clinical application was limited because of the absence of standardized DW-MRI techniques.Key points• DWI provides incremental information for the detection and evaluation of PCa• DWI has moderately high diagnostic accuracy in detecting PCa• Patient condition, imaging protocols and study design positively influence diagnostic performance• General clinical application requires optimization of image acquisition and interpretation

show abstract

Section: Discussionmentioning

confidence: 99%

The value of diffusion-weighted imaging in the detection of prostate cancer: a meta-analysis

2014

View full text Add to dashboard Cite

show abstract

“…The role of power Doppler ultrasound (PDUS) in prostate carcinoma has been the subject of several publications [5][6]. PDUS improves the sensitivity of endorectal ultrasound in spite of some false negative results, demonstrates tumor vascularity, detects capsular extension and aids in imaging guided biopsies.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Power Doppler Ultrasound with Gray Scale Transrectal Ultrasound in Predicting Cancer Positive Prostate Biopsy Cores

Kahraman

Çubuk

Sinanoğlu

et al. 2010

EAJM

View full text Add to dashboard Cite

Objective: The aim of this study is to compare the eff ect of transrectal power Doppler ultrasound (PDUS) and gray scale transrectal ultrasound (TRUS) for the diagnosis of prostate cancer. Materials and Methods:Seventy-six patients evaluated with transrectal PDUS and TRUS underwent eight systematic TRUS guided core-needle biopsies, with additional cores from abnormal areas. Histologic diagnoses were classifi ed as benign prostatic hyperplasia, chronic prostatitis, intraepithelial neoplasia and adenocarcinoma. TRUS and PDUS fi ndings of the cases were recorded.Results: PDUS sensitivity, specifi city, positive predictive value (PPV) and negative predictive values were 81%, 81%, 54% and 94%, respectively. PDUS had a greater sensitivity and specifi city than TRUS (43% and 60%, respectively) and identifi ed cancer cases more accurately (Table 2).Conclusion: Hypervascular foci in PDUS signify suitable zones for biopsy. When combined with systematic TRUS guided biopsy, PDUS increases the cancer detection rate with additional biopsies from suspicious hypervascular foci. Transrectal PDUS guided biopsy should be combined with gray scale TRUS guided biopsy to increase accuracy in the diagnosis of prostate cancer. Bulgular: PDUS duyarlılığı, özgüllüğü , pozitif öngörüsel değeri ve negatif öngörüsel değeri sırasıyla %81, %81, %54 , %94 olarak bulunmuştur. PDUS'un duyarlılığı ve özgüllüğü TRUS'a göre yüksek bulunmuştur (%43 and % 60 respectively) PDUS kanser olgularını daha yüksek doğrulukla saptamaktadır. Sonuç:Prostat Ca tanı ve takibinde gri skala US ve sistematik biopsiler önemli rol oynamaktadır. PDUS biopsi için uygun alanları hipervasküler lezyonlar olarak ortaya koyar. Bu alanlardan alınan ilave biopsiler sonucunda, TRUS ve sistematik biopsi ile kombine bir şekilde kullanıldığında Ca tespit oranını artırır. PDUS eşlikli biopsinin sistematik biopsi ile kombine kullanımı tercih edilmelidir.

show abstract

“…Furthermore in order to facilitate targeted biopsy which has a higher detection rate than conventional biopsies [7], avoiding unnecessary biopsies without missing PCa in men with elevated PSA rather than avoiding annoying biopsies-related complications are aspects that require focus.…”

Section: Discussionmentioning

confidence: 99%

DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis

Ibrahiem

Mohsen

Nabeeh

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

Aim. To evaluate diffusion weighted image-MRI (DWI) as a single diagnostic noninvasive MRI technique for prostate cancer (PCa) diagnosis. Material and Methods. A prospective study was conducted between July 2008 and July 2009. Candidates patients were equal or more than 40 years old, with suspicious digital rectal examination (more than clinical T2) or PSA >4 ng/mL. Informed consent was signed. DWI-MRI was performed at 1.5 T with a body coil combined with a spine coil in consecutive 100 cases. The histopathology of biopsies has been used as reference standard. Two examiners were evaluating MRI and TRUS, both of them were blinded regarding pathological findings. Accuracy, specificity, and sensitivity were statistically analyzed. Results. Based on pathological diagnosis: group A (cancerous); 75 cases and group B (non-cancerous); 25 cases. Mean age was 65.3 and 62.8 years in groups A and B, respectively. Mean PSA was 30.7 and 9.2 ng/mL in groups A and B, respectively. Sensitivity of DWI was 58.3% while specificity was 83.8%. Accuracy of lesion detection was 52.4–77.8% (P < 0.05). Moreover, DWI at ADC value 1.2 × 10−3 mL/sec could determine 82.4% of true positive cases (P < 0.05). ADC values were lower with Gleason score ≥7 (P < 0.05). Conclusion. DWI could represent a non invasive single diagnostic tool not only in detection and localization but also in prediction of Gleason score whenever DWI is used prior to invasive TRUS biopsy. Furthermore, targeted single biopsy could be planned after DWI to minimize patient morbidity by invasive techniques.

show abstract

Optimal combinations for detection of prostate cancer: systematic sextant and laterally directed biopsies versus systematic sextant and color doppler-targeted biopsies

Cited by 14 publications

References 26 publications

The value of diffusion-weighted imaging in the detection of prostate cancer: a meta-analysis

The value of diffusion-weighted imaging in the detection of prostate cancer: a meta-analysis

Comparison of Power Doppler Ultrasound with Gray Scale Transrectal Ultrasound in Predicting Cancer Positive Prostate Biopsy Cores

DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis

Contact Info

Product

Resources

About