Optimal control determination of MMA polymerization in non-isothermal batch reactor using bifunctional initiator

Upreti, Simant R.; Sundaram, Baranitharan Sanmuga; Lohi, Ali

doi:10.1016/j.eurpolymj.2005.06.019

Cited by 14 publications

(6 citation statements)

References 26 publications

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“…Poly(methyl methacrylate) (PMMA) is a glassy amorphous polymer with excellent optical properties, which is extensively used in manufacturing industries because of its high resistance to ultraviolet degradation and corrosion 8. However, PMMA has the disadvantage of poor impact toughness, which makes it unsuitable for many engineering purposes.…”

Section: Introductionmentioning

confidence: 99%

Natural Compounds against Alzheimer’s Disease: Molecular Recognition of Aβ1–42 Peptide by Salvia sclareoides Extract and its Major Component, Rosmarinic Acid, as Investigated by NMR

Airoldi

Sironi

Dias

et al. 2013

Chemistry An Asian Journal

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Amyloid peptides, Aβ1-40 and Aβ1-42, represent major molecular targets to develop potential drugs and diagnostic tools for Alzheimer's Disease (AD). In fact, oligomeric and fibrillar aggregates generated by these peptides are amongst the principal components of amyloid plaques found post mortem in patients suffering from AD. Rosmarinic acid has been demonstrated to be effective in preventing the aggregation of amyloid peptides in vitro and to delay the progression of the disease in animal models. Nevertheless, no information is available about its molecular mechanism of action. Herein, we report the NMR characterization of the interaction of Salvia sclareoides extract and that of its major component, rosmarinic acid, with Aβ1-42 peptide, whose oligomers have been described as the most toxic Aβ species in vivo. Our data shed light on the structural determinants of rosmarinic acid-Aβ1-42 oligomers interaction, thus allowing the elucidation of its mechanism of action. They also provide important information for the rational design of new compounds with higher affinity for Aβ peptides to generate new anti-amyloidogenic molecules and/or molecular tools for the specific targeting of amyloid aggregates in vivo. In addition, we identified methyl caffeate, another natural compound present in different plants and human diet, as a good ligand of Aβ1-42 oligomers, which also shows anti-amyloidogenic activity. Finally, we demonstrated the possibility to exploit STD-NMR and trNOESY experiments to screen extracts from natural sources for the presence of Aβ peptide ligands.

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Section: Introductionmentioning

confidence: 99%

Natural Compounds against Alzheimer’s Disease: Molecular Recognition of Aβ1–42 Peptide by Salvia sclareoides Extract and its Major Component, Rosmarinic Acid, as Investigated by NMR

Airoldi

Sironi

Dias

et al. 2013

Chemistry An Asian Journal

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“…Upreti et al 135 , tempted to achieve different objectives: 1) maximum conversion, 2) minimum time, 3) maximum conversion and normal average molecular weight, and, 4) maximum conversion and weight average molecular weight.…”

Section: B →C+d A+b+c → E+dmentioning

confidence: 99%

Optimal control in reactive processing for fine chemicals and polymers in stirred jacketed batch and semi-batch reactors: A bibliography

Stojkovic

2022

Preprint

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After World War II, scientific investigations for processing in chemical batch reactors were started, for its “most adopted” application in the industrial sector. Taken from the industrial perspective, serious instances, unable to be endured, happen; hence, the process must be in control of, which impedes the realization of batch reactor objectives. Therewithal, with the evolution of large-scale optimization software packages, the “ease” to convert novel optimal control policies into industrial environment strategies, becomes realistic. This work presents a detailed bibliography on the optimal control functioning for reactor configuration named “stirred jacketed”, waged in batch/semi-batch processing of fine chemicals and polymers, along with methods according to this definition. To the author's knowledge, all the existing schemes are discussed, focusing on their strong points.

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“…A commonly studied optimization problem (Chakravarthy et al, 1997;Garg et al, 1999;Lee et al, 1997;Mankar et al, 1999Mankar et al, , 2002Upreti et al, 2005) is to obtain the optimal temperature history (the control or decision variable), T op (t), that minimizes the total reaction time, t f , while simultaneously requiring the final values, x mf , M wf , and PDI f , of the monomer conversion, the weight-average molecular weight and the polydispersity index, respectively, to meet the desired specifications (these being equal to x md , M wd and PDI d , respectively). The adapted jumping gene algorithm, GA-II-aJG (Bhat, 2004;Guria et al, 2005), of the elitist version of genetic algorithm, GA-II (Deb, 2001) is used to obtain the optimal temperature histories for the bulk polymerization of MMA for different values of the initiator loadings, [I ] 0 .…”

Section: Problem Formulationmentioning

confidence: 99%

An experimental study on on-line optimizing control of free radical bulk polymerization in a rheometer–reactor assembly under conditions of power failure

Sangwai

Bhat

Saraf

et al. 2007

Chemical Engineering Science

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Optimal control determination of MMA polymerization in non-isothermal batch reactor using bifunctional initiator

Cited by 14 publications

References 26 publications

Natural Compounds against Alzheimer’s Disease: Molecular Recognition of Aβ1–42 Peptide by Salvia sclareoides Extract and its Major Component, Rosmarinic Acid, as Investigated by NMR

Natural Compounds against Alzheimer’s Disease: Molecular Recognition of Aβ1–42 Peptide by Salvia sclareoides Extract and its Major Component, Rosmarinic Acid, as Investigated by NMR

Optimal control in reactive processing for fine chemicals and polymers in stirred jacketed batch and semi-batch reactors: A bibliography

An experimental study on on-line optimizing control of free radical bulk polymerization in a rheometer–reactor assembly under conditions of power failure

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