Optimal control of reaching is disturbed in complex regional pain syndrome: a single-case study

Osumi, Michihiro; Sumitani, Masahiko; Kumagaya, Shinichiro; Morioka, Shu

doi:10.2147/jpr.s118846

Cited by 11 publications

(7 citation statements)

References 31 publications

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“…Repeated painful surgery on the extremity would require the discussion of a Complex Regional Pain Syndrome (CRPS), but the complete absence of trophic disturbances is incongruous. Case reports of tremor have been described but only after markable deafferentation not fitting well in this case [24]. There were no signs of bradykinesia and Parkinson's syndrome, nor evidence of essential or enhanced physiological tremor.…”

Section: Case Reportmentioning

confidence: 52%

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Diagnosis and therapy of functional tremor a systematic review illustrated by a case report

Bartl

Kewitsch

Hallett

et al. 2020

Neurol. Res. Pract.

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Background Diagnosis of functional movement disorders and specifically functional tremor (FT) (representing 50% of them) remains demanding. Additionally, due to heterogeneity of the disorders, structured concepts and guidelines for diagnosis and therapy are difficult to establish. Ascertaining the state of knowledge to derive instructions for operating procedures is the aim of this review. Main text Based on a standardized systematic literature research using the term “psychogenic tremor” in the MEDLINE database dating back ten years, 76 studies were evaluated. Conventional features of FT are variability of frequency and amplitude. Further, response to distraction by motor and cognitive tasks is a key diagnostic feature in differentiation between organic and functional origin. A variety of electrophysiological tests have been evaluated including surface electromyography and accelerometry to establish laboratory-supported criteria for diagnosing tremor. Also, finger tapping tests have been used to identify FT, showing positive potential as supplementary evidence. Imaging studies in general are mostly underpowered and imaging cannot be used on an individual basis. Therapeutic studies in FT often have a diagnostic component. Cognitive behavioral therapy should be the preferred psychological treatment independent of additional psychiatric symptoms. Other psychotherapeutic methods show lack of evidence concerning FT. Relaxation techniques and physiotherapy are an important additional feature, especially in children and adolescents. In regard to drug therapy, randomized and blinded trials are not available. A significant decrease in rating scales could be detected after active, not sham repetitive transcranial magnetic stimulation with a long-lasting effect. Also root magnetic stimulation seems to be effective. The clinical feature of tremor entrainment in FT can be used in combination with biofeedback as so-called tremor retrainment, using self-modulation of frequency and severity, to bring the movements under volitional control. Conclusion Diagnosis and treatment of FT is challenging and should include a combination of intensive clinical examination and targeted addition of standardized testing, especially electrophysiological methods. Often therapeutic effects have a diagnostic component. A multimodal strategy, considering psychological factors as a potential origin as well as maintaining effects seems to be most effective.

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Section: Case Reportmentioning

confidence: 52%

“…A passive fixation of the hand led to an increase of the symptoms in the arm and in the shoulder. This phenomenon is described as "whack-amole" sign in patients with functional movement disorders (Video Entrainment_Coactivation) [24].…”

Section: Case Reportmentioning

confidence: 99%

Diagnosis and therapy of functional tremor a systematic review illustrated by a case report

Bartl

Kewitsch

Hallett

et al. 2020

Neurol. Res. Pract.

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“…Previous studies have demonstrated that patients with strokes or pathological pain suffer distorted limb ownership and an inability to perceive their affected limbs as a part of their bodies (Galer and Jensen, 1999 ; Frettlöh et al, 2006 ; Burin et al, 2015 ). Additionally, other studies showed a decrease of movements accuracy (Bank et al, 2015 ; Osumi et al, 2017 ). This our result may be useful for grasping the extent of temporal incongruence of the patient’s sensory movement by evaluating the change in body perception and movement disorders felt by the patient.…”

Section: Discussionmentioning

confidence: 84%

Neural Mechanism of Altered Limb Perceptions Caused by Temporal Sensorimotor Incongruence

Katayama

Tsukamoto

Osumi

et al. 2018

Front. Behav. Neurosci.

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Previous studies have demonstrated that patients with strokes or pathological pain suffer distorted limb ownership and an inability to perceive their affected limbs as a part of their bodies. These disturbances are apparent in experiments showing time delays between motor commands and visual feedback. The experimental paradigm manipulating temporal delay is considered possible to clarify, in detail, the degree of altered limb perception, peculiarity and movement disorders that are caused by temporal sensorimotor incongruence. However, the neural mechanisms of these body perceptions, peculiarity and motor control remain unknown. In this experiment, we used exact low-resolution brain electromagnetic tomography (eLORETA) with independent component analysis (ICA) to clarify the neural mechanisms of altered limb perceptions caused by temporal sensorimotor incongruence. Seventeen healthy participants were recruited, and temporal sensorimotor incongruence was systematically evoked using a visual feedback delay system. Participants periodically extended their right wrists while viewing video images of their hands that were delayed by 0, 150, 250, 350 and 600 ms. To investigate neural mechanisms, altered limb perceptions were then rated using the 7-point Likert scale and brain activities were concomitantly examined with electroencephalographic (EEG) analyses using eLORETA-ICA. These experiments revealed that peculiarities are caused prior to perceptions of limb loss and heaviness. Moreover, we show that supplementary motor and parietal association areas are involved in changes of peculiarity, limb loss, heaviness and movement accuracy due to temporal sensorimotor incongruence. We suggest that abnormalities in these areas contribute to neural mechanisms that modify altered limb perceptions and movement accuracy.

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“…In general, individuals with a musculoskeletal disorder tend to make their daily movements slowly. The experience of pain after movements can slow their daily movements 29,30 , but the daily movements remain slow even after pain alleviation 31,32 . It has been suggested that not pain but rather the fear of movement makes daily movements slow 23,33 .…”

Section: Discussionmentioning

confidence: 99%

Kinematic changes in goal-directed movements in a fear-conditioning paradigm

Nishi

Osumi

Sumitani

et al. 2021

Sci Rep

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In individuals with a musculoskeletal disorder, goal-directed reaching movements of the hand are distorted. Here, we investigated a pain-related fear-conditioning effect on motor control. Twenty healthy participants (11 women and 9 men, 21.7 ± 2.7 years) performed a hand-reaching movement task. In the acquisition phase, a painful electrocutaneous stimulus was applied on the reaching hand simultaneous with the completion of reaching. In the subsequent extinction phase, the task context was the same but the painful stimulus was omitted. We divided the kinematic data of the hand-reaching movements into acceleration and deceleration periods based on the movement-velocity characteristics, and the duration of each period indicated the degree of impairment in the feedforward and feedback motor controls. We assessed the wavelet coherence between electromyograms of the triceps and biceps brachii muscles. In the acquisition phase, the durations of painful movements were significantly longer in both the acceleration and deceleration periods. In the extinction phase, painful movements were longer only in the acceleration period and higher pain expectation and fear were maintained. Similarly, the wavelet coherence of muscles in both periods were decreased in both the acquisition and extinction phases. These results indicate that negative emotional modulations might explain the altered motor functions observed in pain patients.

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Optimal control of reaching is disturbed in complex regional pain syndrome: a single-case study

Cited by 11 publications

References 31 publications

Diagnosis and therapy of functional tremor a systematic review illustrated by a case report

Diagnosis and therapy of functional tremor a systematic review illustrated by a case report

Neural Mechanism of Altered Limb Perceptions Caused by Temporal Sensorimotor Incongruence

Kinematic changes in goal-directed movements in a fear-conditioning paradigm

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