This study proposed a mathematical model for designing a feeder transit service for improving the service quality and accessibility of transportation hubs (such as airport and rail station). The proposed model featured an integrated framework, which simultaneously guided passengers to reach their nearest stops to get on and off the bus, designed routes to transport passengers from these selected pick-up stops to the transportation hubs, and calculated their departure frequencies. In particular, the maximum walking distance, the upper and lower limits of route frequencies, and the load factor rate of each route were fully accounted for in this study. The main objective of the proposed model was to simultaneously minimize the total walking, riding time, and waiting time of all passengers. As this study explored an NP-hard problem, a two-stage genetic algorithm combining the Dijkstra search method was further developed to yield metaoptimal solutions to the model within an acceptable time. Finally, a test instance in Chongqing City, China, demonstrated that the proposed model was an effective tool to generate a pedestrian, route, and operation plan; it reduced the total travel time, compared with the traditional model.