“…Such collimators generally weigh more than permitted by standard camera gantries, and thus, optimizing collimators for high energy applications has become a well-known challenge in nuclear medicine. 16 In this paper, we extend our previous initial work on low energy convergent collimator optimization 17 and propose an optimization method for high energy applications where the weight limit or the desired septal penetration can be used as input parameters. These high energy collimators could be used to image radioisotopes such as 131 I (364 keV) and positron emitter radioisotopes (511 keV), which are used in tumor quantification studies 18,19 and in simultaneous dualisotope ( 99m Tc and FDG) SPECT imaging, 20, 21 respectively.…”