The target of this paper is to develop an enhanced flow-thermo-structural (FTS) model with high computational accuracy, to perform the integrated analysis of film cooling nozzle guide vane (NGV). An efficient turbulence model and weak spring approach are utilized in the enhanced FTS model. In respect of the power balance principle of aeroengine rotor shaft and temperature test of a typical combustor, the mean temperature inlet and five normalization temperature curves were confirmed, respectively. The temperature-sensitive paint (TSP) technology was used to verify the numerical simulation. From this study, we find that the predicted temperature caters for the TSP test well, between which the maximum error is less than 6%, and the maximum thermal stress is 758 MPa around the hole edges and the location of stress concentration keeps the consistency with that of the cracks. The maximum thermal stress increases by 10% with the increasing inlet temperature and reduces by about 16% with the shifting of flame peak from the outer to inner hub. The prediction provides general information on the initiation of cracks on a vane segment. The developed enhanced FTS model is validated to be workable and precise in the integrated analysis of film cooling NGV. The efforts of this study provide an integrated analysis approach of film cooling NGV and are promising to provide guidance for the integrated design of film cooling components besides NGV.