Background: N6-methyladenosine (m 6 A) RNA methylation is dynamically and reversibly regulated by methyl-transferases ("writers"), binding proteins ("readers"), and demethylases ("erasers"). The m 6 A is restored to adenosine and thus to achieve demethylation modification. The abnormality of m 6 A epigenetic modification in cancer has been increasingly attended. However, we are rarely aware of its diagnostic, progressive and prognostic performance in lung adenocarcinoma (LUAD). Methods and Results: The expression of 13 widely reported m 6 A RNA regulators in LUAD and normal samples were systematically analyzed. There were 12 m 6 A RNA methylation genes displaying aberrant expressions, and an 11-gene diagnostic score model was finally built (Diagnostic score

The method of lubrication for piston ring in some types of low-speed two-stroke marine diesel engines is completely different from those in medium- or high-speed diesel engines since the inner surface of cylinder liners are textured with elliptical grooves in macroscale and honing texture in microscale. In this paper, a numerical model has been developed to study the potential of use of cylinder bore surface texturing, in the form of circumferential oil grooves with different dimensions and densities, to improve the tribological properties of piston ring–cylinder liner tribosystem. The average Reynolds equation has been employed in the area of microscale texture and the effect of macroscale grooves has been incorporated to improve the currently lubrication model. The focus is put on cavitation formation condition and boundary condition in grooves within the area of lubrication, analysis of the effect of macrogroove dimension characters and distribution of grooves on the tribological performance of piston compression ring. The solution provides the hydrodynamic friction force, boundary friction force, coefficient of friction, and the total friction force. The results show that the cylinder liner oil grooves can efficiently be used to maintain hydrodynamic effect. It is also shown that optimum surface texturing may substantially reduce the friction losses between piston ring and cylinder liner.

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The process of wet compression in an axial compressor is an intricate two-phase fiow involving not only heat and mass transfer processes but also droplet breakup and even formation of discontinuous water film on the blade surface and then breaking into droplets. In this paper, the droplet-wall interactions are analyzed using the theory of .spray wall impingement through two computational models for an isolated transonic compressor rotor (NASA rotor 37). Model 1, representing spread phenomenon, assumes that all droplets impacting on the blade are trapped in the water film and subsequently released from its trailing edge and enter the wake region with an equivalent mass flow but bigger in diameter and smaller in number. Whereas, the model 2, representing splashing phenomenon, assumes that upon impacting on the blade, the droplets will breakup into many smaller ones. The three-dimensional fiow simulation results of these two models are analyzed and compared in this paper.

Thermodynamic model of wet compression process is established in this paper. The topics of ideal wet compression process, actual wet compression process, water droplet evaporative rate, wet compression work, inlet evaporative cooling, concept of wet compression efficiency, aerodynamic breaking of water droplets etc. are investigated and discussed in this paper.