Assessment of the stability/boundedness of solutions to nonlinear systems with variable coefficients brings long-standing and challenging problems which emerge in various application domains. These problems are naturally evolved into more arduous and largely open problems concerned with the estimation of the corresponding stability/boundedness regions. This paper develops a novel approach furnishing computationally tractable boundedness/stability criteria which underscores a methodology providing recursive estimation of the boundaries of the trapping/stability regions for a broad class of multidimensional and nonlinear systems with variable nonperiodic coefficients. Furthermore, our approach naturally conveys the bilateral bounds for the norms of solutions to the corresponding systems via the application of successive approximations which are introduced in this paper.The developed techniques are validated in inclusive simulations which endorse their applications to systems with large and complex nonlinear components and bounded in-norm time-varying disturbances.