Optimal dose of rocuronium bromide undergoing adenotonsillectomy under 5% sevoflurane with fentanyl

Neuromuscular‐blocking agents for tracheal intubation in pediatric patients (0‐12 years): A systematic review and meta‐analysis

“…In a number of studies, anesthesia induction was preceded by midazolam 0.50 mg/kg PO (310 pts), 0.3‐1 mg/kg rectal (198 pts), or 0.05‐0.10 mg/kg IV (340 pts) . Anticholinergic medication was administered after intravenous access was established (569 pts) or as appropriate to treat hypotension or bradycardia. Lidocaine 0.2‐1.5 mg/kg was given to prevent pain caused by propofol injection.…”

“…We identified 22 RCTs with 1651 ASA class I‐II patients in 62 treatment groups (Figure and Table ) that were conducted between 1993 and 2018. Clinical reports of all studies were published as peer‐reviewed full journal articles. Participants were recruited over a period of 26 years (1993‐2018) from different parts of the world.…”

“…The method to calculate the sample size required before embarking on data collection was not reported in 6/22 of the enrolled studies . Intubation conditions were assessed using either a 3‐item (7/22) or 5‐item (15/22) scoring system. In three trials, primary outcome (excellent intubation conditions) was not addressed .…”

“…In three trials, primary outcome (excellent intubation conditions) was not addressed . Several studies reported no or only partial hemodynamic data. Magnitude and time course of neuromuscular block was monitored in five studies, that is, by mechanomyography or by acceleromyography …”

“…Endotracheal intubation was facilitated by either atracurium (14 pts), mivacurium (28 pts), rocuronium (290 pts), succinylcholine (398 pts), vecuronium (30 pts), or no muscle relaxant at all (821 pts). No placebo‐controlled RCTs could be found regarding intubation conditions obtained by cisatracurium in children.…”