Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device

Luján, Emmanuel; Schinca, H.; Olaiz, Nahuel Manuel; Urquiza, Santiago; Molina, Fernando V.; Turjanski, Pablo; Marshall, Guillermo

doi:10.1016/j.electacta.2015.10.147

Cited by 14 publications

(12 citation statements)

References 18 publications

(26 reference statements)

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“…Lujan et al therefore introduced a theoretical model for using coulomb dosage as a reliable parameter for determination of doseresponse relationship. [27] The proposed model is based on the 2D Nernst-Planck equations for ion transport of four chemical species, being H + , OH À , Cl À , Na + with the assumption that electroneutrality and Butler-Volmer conditions are met at the electrode interfaces. The proposed theory predicts the formation of an initial neutral pH profile that evolves into two halfspherical pH fronts, one basic and the other acid (from cathode and anode, respectively), which expand towards the periphery until a distorted sphere is established.…”

Section: Optimization Of Echt Dose-response: Variations In Applied Cumentioning

confidence: 99%

“…Lujan et al. therefore introduced a theoretical model for using coulomb dosage as a reliable parameter for determination of dose‐response relationship . The proposed model is based on the 2D Nernst‐Planck equations for ion transport of four chemical species, being H + , OH − , Cl − , Na + with the assumption that electroneutrality and Butler‐Volmer conditions are met at the electrode interfaces.…”

Section: Advancements In Echtmentioning

confidence: 99%

“…Predicted (lines) and experimental (marker), respectively, NTV vs. coulomb dosage. Adapted with permission from Ref [27]…”

mentioning

confidence: 99%

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Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

O’Brien

Ignaszak

2020

ChemElectroChem

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Electrochemical therapy (EChT) is an evolving technique that allows for the minimally invasive ablation of tumors and cancers through the application of direct current (DC). The therapy boasts a low cost in comparison to many standardized procedures and could be made one of the most accessible forms of minimally invasive procedures for the targeting of tumors, owing to not only cost but also surgical simplicity. Furthermore, the treatment removes the need for oncospecific drugs and major surgical procedures, can be used when typical therapies are ill-advised, and has shown clinical success in China, Brazil, Cuba, and Germany. Here, we will explore the new technologies, mathematical models, proposed mechanisms, and applications of EChT; as these develop, EChT may soon find itself at the forefront of the oncological world.

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Section: Optimization Of Echt Dose-response: Variations In Applied Cumentioning

confidence: 99%

Section: Advancements In Echtmentioning

confidence: 99%

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Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

O’Brien

Ignaszak

2020

ChemElectroChem

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“…In Luján et al (2015) dose planning in EA was addressed for the first time through in silico modeling using the Nernst-Planck equations for ion transport validated with data taken from Olaiz et al (2010b). Here, the dose planning methodology is presented in detail.…”

Section: Electric Field-based Tumor Treatments: Electrolytic Ablationmentioning

confidence: 99%

“…The Coulomb dose is obtained for a fixed electric current as a function of the time elapsed through the numerical simulation of the experimental EA model previously described. The numerical simulation uses the Poisson-Nernst-Planck equations describing electric field and ion transport in an electrolyte with four components; see details in Luján et al (2015). Damage is indirectly obtained numerically tracking the pH front in space and time during the EA simulation.…”

Section: Electric Field-based Tumor Treatments: Electrolytic Ablationmentioning

confidence: 99%

Mass Transfer of Electrolytic Species During Electric Field-Based Tumor Treatments

Marshall¹

2016

Handbook of Electroporation

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The amount of electrolytic products emerging from chemical reactions is proportional to the amount of electric charges or Coulomb dose passing through the tissue; thus, Coulomb dose is proportional to tissue damage. Theory shows that in a constant electric field such as in electrolytic ablation, an optimal dose-response relationship is the minimum Coulomb dose necessary to achieve total tumor destruction while minimizing healthy tissue damage. In a pulsed electric field such as in gene electrotransfer, unwanted damage due to electrolysis is non-negligible; here, an optimal gene electrotransfer treatment is predicted as the critical Coulomb dose yielding maximum electroporated area with minimum damage. Theory shows that when tissue natural buffer is taken into account, damage is attenuated (though still remaining non-negligible), and the critical Coulomb dose for optimal gene electrotransfer increases.

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Mass Transfer of Electrolytic Species During Electric Field-Based Tumor Treatments

Marshall¹

2017

Handbook of Electroporation

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Optimal dose-response relationship in electrolytic ablation of tumors with a one-probe-two-electrode device

Cited by 14 publications

References 18 publications

Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

Advances in the Electrochemical Treatment of Cancers and Tumors: Exploring the Current Trends, Advancements, and Mechanisms of Electrolytic Tumor Ablation

Mass Transfer of Electrolytic Species During Electric Field-Based Tumor Treatments

Mass Transfer of Electrolytic Species During Electric Field-Based Tumor Treatments

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