Optimal Feeding Strategy in Fermentation of Docosahexaenoic Acid Production by Schizochytrium sp.

Abstract

Fed-batch fermentation has the potential to increase the production of docosahexaenoic acid (DHA) in Schizochytrium sp. which can provide additional nutrients. The feeding strategy in fed-batch fermentation is one of the important aspects that could help in improving the DHA yield. An enhanced scatter search (eSS) method and the control vector parametrization (CVP) approach were applied to generate the optimal feeding trajectory numerically. Three objective functions were considered, namely, maximizing the DHA concentration, minimizing the final time, and maximizing the economic function. The shortest time and maximum DHA could be determined simultaneously from the optimal feeding trajectory in maximizing the economic function.

Production of ginsenoside compound K from American ginseng extract by fed-batch culture of Aspergillus tubingensis

“…The inhibition of enzymatic reactions caused by high concentrations of substrate is reduced by the fed-batch fermentation process (Qu et al 2013 ). In the process, it is important to maintain a low concentration of carbon source during fermentation (Rohman et al 2022 ). Fed-batch fermentation of reactant as a precursor for biotransformation has also been used because of its inhibition of cell growth at high concentrations (Gomes et al 2012 ; Park et al 2006 ).…”