This paper is concerned with the least-squares linear centralized estimation problem in multi-sensor network systems from measured outputs with uncertainties modeled by random parameter matrices. These measurements are transmitted to a central processor over different communication channels, and owing to the unreliability of the network, random one-step delays and packet dropouts are assumed to occur during the transmissions. In order to avoid network congestion, at each sampling time, each sensor’s data packet is transmitted just once, but due to the uncertainty of the transmissions, the processing center may receive either one packet, two packets, or nothing. Different white sequences of Bernoulli random variables are introduced to describe the observations used to update the estimators at each sampling time. To address the centralized estimation problem, augmented observation vectors are defined by accumulating the raw measurements from the different sensors, and when the current measurement of a sensor does not arrive on time, the corresponding component of the augmented measured output predictor is used as compensation in the estimator design. Through an innovation approach, centralized fusion estimators, including predictors, filters, and smoothers are obtained by recursive algorithms without requiring the signal evolution model. A numerical example is presented to show how uncertain systems with state-dependent multiplicative noise can be covered by the proposed model and how the estimation accuracy is influenced by both sensor uncertainties and transmission failures.