Multi-objective nature-inspired-based approaches are powerful optimizing algorithms to solve the multiple objectives in NP-complete engineering design problems. This chapter proposes a nature-inspired-based modified multi-objective big bang-big crunch (M-MOBB-BC) optimization algorithm to find the Optimal Golomb rulers (OGRs) in a reasonable timeframe. The OGRs have their important application as channel-allocation algorithm that allow suppression of the four-wave mixing crosstalk in optical wavelength division multiplexing systems. The presented simulation results conclude that the proposed hybrid algorithm is superior to the existing conventional classical algorithms, namely extended quadratic congruence and search algorithm and nature-inspired-based algorithms, namely genetic algorithms, biogeography-based optimization, and simple BB-BC optimization algorithm to find near-OGRs in terms of ruler length, total occupied optical channel bandwidth, bandwidth expansion factor, computation time, computational complexity, and non-parametric statistical tests.