“…For this reason, several mathematical models have appeared to improve equipment allocations where the cost is typically minimized. These plant layout models have resolved one-floor (Barbosa-Póvoa, Mateus, & Novais, 2001;Georgiadis, Schilling, Rotstein, & Macchietto, 1999), 2D multi-floor (Jayakumar & Reklaitis, 1994Papageorgiou & Rotstein, 1998;Patsiatzis & Papageorgiou, 2002), and even 3-D ( Barbosa-Póvoa, Mateus, & Novais, 2002;Georgiadis, Rotstein, & Macchietto, 1997;Westerlund, Papageorgiou, & Westerlund, 2007) problems.…”