Optimal operation of simulated moving bed chromatographic processes by means of simple feedback control

Schramm, H.; Grüner, Stefan; Kienle, Achim

doi:10.1016/s0021-9673(03)00946-4

Cited by 55 publications

(27 citation statements)

References 11 publications

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“…Various suggestions to obtain these results faster and more efficiently have been made (e.g., [20][21][22]). This interesting aspect as well as new and promising concepts to control SMB processes [e.g., [23][24][25][26], will not be further discussed here.…”

Section: Classical Simulated Moving Bed Chromatographymentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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Chromatographic separation processes are widely used to isolate and purify value added products. Most frequently, such separation processes are performed exploiting the principles of injecting samples of the feed mixture in a repetitive periodic manner and collecting the target products batchwise. In the early 1960s, an alternative operation principle based on using several columns connected in series and exploiting a continuous countercurrent movement between the mobile and stationary phases initiated significant improvements in performing specific separation processes in the petrochemical and sugar industries. In the last decade, the so-called simulated moving bed (SMB) chromatography has rapidly entered the pharmaceutical industry. In particular enantioseparations using chiral stationary phases have become a strong driving force to develop more sophisticated concepts of continuous chromatography. Currently, the growing interest in efficient methods for the downstream processing of biomolecules enhances interest in SMB processes. This paper gives a brief overview of the new suggestions and trends. © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim [accessed July 4, 2008

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Section: Classical Simulated Moving Bed Chromatographymentioning

confidence: 99%

New Developments in Simulated Moving Bed Chromatography

2008

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“…Most approaches considered model predictive control (e.g., [14][15][16][17][18]). Alternative concepts are input-output linearization [19] or simple PI controllers in combination with concepts from nonlinear wave propagation [20]. Most recently, nonlinear wave propagation was also used to find a simple and efficient problem and controller formulation in discrete time [21,22].…”

Section: Introductionmentioning

confidence: 99%

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

Swernath¹,

Kaspereit²,

Kienle³

2013

Chem Eng & Technol

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The combination of continuous chromatographic processes and subsequent crystallization with a recycle of the mother liquor can improve significantly the efficiency of separation processes for the production of enantiomers if compared to the stand-alone chromatographic process. For the first time, dynamic operability and plantwide control of such a process combination is investigated. In the first step, the effect of disturbances on the open loop dynamics is evaluated. In a second step, a simple plantwide control strategy is proposed in order to ensure a robust process operation. It is demonstrated that the direct control of the simulated moving bed (SMB) unit is not required to stabilize the process combination while maintaining the desired product specifications. Instead, this can be achieved easily by controlling the amount of solvent removed or added to the system.

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“…The first control concepts were projected based on a True Moving Bed (TMB) [1,2]. Unfortunately, this artificially established process is not able to describe the periodic changes of the concentrations at the drains.…”

Section: Introductionmentioning

confidence: 99%

“…First approaches on control designs using low order models can be found in work by Schramm et al [2] and Kleinert and Lunze [5]. These make use of the movement of the concentration fronts in a different manner.…”

Section: Introductionmentioning

confidence: 99%

An Adaptive Control Concept for Simulated Moving Bed Plants in Case of Complete Separation

Fütterer

2008

Chem Eng & Technol

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Simulated Moving Bed (SMB) technology has played an important role in the separation of binary mixtures. An exact adjustment of the volumetric flow rates is necessary for trouble-free operation. In this contribution, an adaptive control concept is introduced that determines the necessary control variables for complete automatic separation. A simple model is derived for the movement of the concentration fronts and a controller is developed based on the model. The simulation result shows the potential of applying such a control design for application in industrial use.

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Optimal operation of simulated moving bed chromatographic processes by means of simple feedback control

Cited by 55 publications

References 11 publications

New Developments in Simulated Moving Bed Chromatography

New Developments in Simulated Moving Bed Chromatography

Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers

An Adaptive Control Concept for Simulated Moving Bed Plants in Case of Complete Separation

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