Optimal response surface design of Gum tragacanth-based poly[(acrylic acid)-co-acrylamide] IPN hydrogel for the controlled release of the antihypertensive drug losartan potassium

Abstract

The present study proposes the development and optimization of a new interpenetrating polymer network (IPN), consisting of Gum tragacanth, poly(acrylic acid) (PAA), and poly(acrylamide) (PAAm), for the in situ controlled release of losartan potassium under different pH conditions at 37 °C.

Biodegradation study of enzymatically catalyzed interpenetrating polymer network: Evaluation of agrochemical release and impact on soil fertility

“…After attaining the swelling equilibrium, the swollen sample was separated from the water by filtering using 100- mesh sieve. The percentage swelling ( P s ) of the interpenetrating polymer network was calculated from the following equation [23] [25].$P_{\mathrm{normals}}=\frac{W_{\mathrm{normals}}-W_{\mathrm{normald}}}{W_{\mathrm{normald}}}\times 100$where W s and W d are weight of swollen and dry polymer, respectively.…”

Evaluation of a conducting interpenetrating network based on gum ghatti-g-poly(acrylic acid-aniline) as a colon-specific delivery system for amoxicillin trihydrate and paracetamol

“…8 As mentioned earlier for colon-specific drug delivery, pH-sensitive hydrogels play an important role in a stimuli-responsive manner based on pH changes in GIT. 13 Gastrointestinal release of amoxicillin through the synthesized IPNs based on chitosan, poly(N-vinyl pyrrolidene) and poly(acrylic acid) was reported by Ekici and Saraydin. 10 Interpenetrating network (IPN) structured hydrogels containing natural polysaccharides have also been studied as good alternatives for drug release matrices.…”

Biodegradation of Gum tragacanth acrylic acid based hydrogel and its impact on soil fertility

“…Cylindrical bead of the hydrogel was immersed in the solution for 24 h, so that potassium chloride molecules could absorb into the synthesized hydrogel matrix. Swollen sample was taken out and washed properly with water to abstract surface adhered potassium chloride molecules followed by drying at 50 C. Evaluation of potassium chloride release kinetics with respect to time was studied and after every 4 h time interval concentration of the potassium chloride release was taken until equilibrium was attained [16,17,19]. …”

“…'n' ¼ 0.5 revealed the normal Fickian diffusion, the value of 'n' ¼ 1.0, signifies Case II diffusion and if the value of 'n' lies between 0.5 and 1.0 it showed non-Fickian or anomalous diffusion. Potassium chloride release behaviour through synthesized device was evaluated using Ritger-Peppas equation [16,17,19]:…”