Optimal Serum 25(OH)D Levels and Vitamin D Intake in Korean Postmenopausal Women

Abstract

Vitamin D plays a crucial role in regulating the growth and maintenance of the musculoskeletal system. Postmenopausal women are vulnerable to bone fractures because of the decrease in bone mineral density (BMD). Therefore, this study aimed to identify the determinants that influence BMD and the 25(OH)D levels in Korean postmenopausal women. This study collected general and dietary intake information, measured biochemical indices, and conducted BMD tests in 96 postmenopausal women residing in a metropolitan area in Korea. This study analyzed factors that influenced serum 25-hydroxyvitamin D (25(OH)D) and BMD, as well as the correlation between the intact parathyroid hormone (iPTH) and serum 25(OH)D levels. The serum 25(OH)D levels increased by 0.226 ng/mL in the summertime, 0.314 ng/mL in the wintertime, and 0.370 ng/mL on annual average when vitamin D intake rose by 1 µg/1000 kcal. When the serum 25(OH)D levels were ≥18.9 ng/mL, the iPTH levels did not rapidly increase. To maintain the serum 25(OH)D levels at ≥18.9 ng/mL, a daily vitamin D intake of ≥13.21 µg was required. Consequently, consuming vitamin D-fortified foods or vitamin D supplements is necessary to improve both bone health and vitamin D nutritional status.

Efeitos Da Suplementação De Vitamina D Em Mulheres Na Pós-Menopausa: Uma Revisão De Literatura

“…Outros dois estudos também relataram que a deficiência de vitamina D prejudica a mineralização óssea devido a absorção ineficiente de cálcio e fósforo, o que se associa com o aumento na concentração sérica do paratormônio (PTH). Com isso, tais estudos verificaram que a suplementação de vitamina D promove um aumento da concentração plasmática da mesma, o que promove efeitos benéficos para a saúde óssea (SHIN et al, 2023;NAHAS-NETO et al, 2018). Já no estudo de Hassanein e colaboradores (2023) foi constatado que as mulheres na pós menopausa são as mais afetadas pela deficiência de vitamina D, mas por outro lado são as mais propensas a se beneficiarem da suplementação.…”

Vitamin D and epilepsy: are anti-epileptic drugs a double-edged sword? Perspective from low- and middle-income countries

“…The cultural obsession with lighter and untanned skin in some of these countries [ 7 ] has created an inclination to avoid the sun, predisposing the population to vitamin D deficiency; this effect is further compounded by EIAEDs. Bone pain and muscle weakness, depression and fatigue, and stunted growth and development in children are common clinical features of vitamin D deficiency [ 8 ]. These comorbidities could lead to a sense of hopelessness in patients and thus deteriorates their mental health and their motivation to recover.…”