Optimal synthesis of mesostructured hollow titania nanotubes templated on CaCO3 nanoparticles

Hou, Qian; Tao, Xia; Yang, Yunjie; Ma, Yi

doi:10.1016/j.powtec.2009.12.012

Cited by 9 publications

(6 citation statements)

References 41 publications

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“…Moreover, relative to the spectra of plain TiO 2 systems (T‐600), all of the investigated systems exhibit the typical OH pattern for titania, i.e. : 1) A complex band in the range 3600–3700 cm −1 , which can be ascribed on the basis of its spectroscopic behavior and literature data23 to the stretching mode (νOH) of TiOH species that are free from hydrogen‐bonding interactions; and 2) a broad envelope in the range 3600–3000 cm −1 , which can be ascribed to the νOH mode of all of the hydrogen‐bonded OH groups that are present at the surface of the solid 24. This result is not surprising because activation in vacuo at RT can only remove the physisorbed fraction of (associated/undissociated) water molecules that are present at the surface of the various TiO 2 systems.…”

Section: Resultsmentioning

confidence: 83%

“…Many studies have reported the preparation of nanostructured titanium‐based DDSs. In particular, these studies have focused on either the use of titania nanotubes or on sol–gel‐derived matrices to sustain the release of antibiotics, anti‐inflammatories, or anti‐tumor drugs 20–23. Recently,24 we investigated the ability of a series of commercial TiO 2 matrices to control the release of ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

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Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

Ghedini

Nichele

Signoretto

et al. 2012

Chemistry A European J

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A series of titanium oxides was prepared by using a surfactant-template method (STM) and used as a carrier for the sustained release of ibuprofen, which was chosen as a model drug. This STM provides an efficient route to TiO(2) matrices with both high surface area (when compared with those that were obtained by using traditional synthetic approaches) and well-defined mesoporous textures. Some parameters of the synthetic procedure were varied: pH value, surfactant, and thermal treatment. The physicochemical nature of the surface carriers were investigated by means of N(2) -physisorption measurements and FTIR spectroscopy. The effect of the amount of drug on the release kinetics was also investigated. The drug delivery was evaluated in vitro in four different physiological solutions (that simulated the gastrointestinal tract) to analyze the behavior of the TiO(2) -based systems if they were to be formulated as oral DDSs. Our optimized approach is a good alternative to the classical methods that are used to prepare efficient TiO(2) -based drug-delivery systems.

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Section: Resultsmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

Ghedini

Nichele

Signoretto

et al. 2012

Chemistry A European J

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“…Release kinetics are divided into zero order release, first order release, the Higuchi model, etc. [152][153][154]. Zero-order release is a constant-rate release, usually observed in oral, transdermal drug delivery [155].…”

Section: Single Mode Releasementioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.

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“…These studies deal with either polymeric materials and/or with inorganic oxides, such as nanoporous alumina, porous silicon, nanostructured ceramics and nanostructured TiO2 [1][2][3]. Among these systems titanium and TiO2 materials are well known in the biomedical applications since the 1970s for their use as orthopaedic implants.…”

Section: Introductionmentioning

confidence: 99%

“…Several works concerning the use of TiO2 nanotubes as drug carriers have been published [6][7][8]; in particular, Popat et al [9] have studied and reported the effect of titania nanotubes templates as sustained drug release platforms for the treatment of acute infections arising after orthopaedic implant surgeries. These studies evidenced that titania nanotemplate carriers are not only effective against the bacterial infection but, parallel to this, they exhibit improved osteoblast cell adhesion and growth.…”

Section: Introductionmentioning

confidence: 99%

Effect of textural properties on the drug delivery behaviour of nanoporous TiO2 matrices

Signoretto

Ghedini

Nichele

et al. 2011

Microporous and Mesoporous Materials

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In this work several nanoporous titania powders have been considered as potential carriers for the sustained release of ibuprofen, used as model drug. The textural features and the physico-chemical nature of the surface carriers have been investigated by means of N2 physisorption measurements and FT-IR analyses. The delivery profiles have been collected in vitro in physiological solution at pH 7.4, maintaining the temperature at 37°C. It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers, in particular for what concerns their pores dimension. The choice of the proper synthetic approach allows a high control of the properties of the final material and of its behaviour in the drug delivery process that can be controlled to a very high extent

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Optimal synthesis of mesostructured hollow titania nanotubes templated on CaCO3 nanoparticles

Cited by 9 publications

References 41 publications

Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

Hollow structures as drug carriers: Recognition, response, and release

Effect of textural properties on the drug delivery behaviour of nanoporous TiO2 matrices

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Optimal synthesis of mesostructured hollow titania nanotubes templated on CaCO3 nanoparticles

Cited by 9 publications

References 41 publications

Structure‐Directing Agents for the Synthesis of TiO2‐Based Drug‐Delivery Systems

Structure‐Directing Agents for the Synthesis of TiO2‐Based Drug‐Delivery Systems

Hollow structures as drug carriers: Recognition, response, and release

Effect of textural properties on the drug delivery behaviour of nanoporous TiO2 matrices

Contact Info

Product

Resources

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Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems

Structure‐Directing Agents for the Synthesis of TiO₂‐Based Drug‐Delivery Systems