Optimal threshold of a control parameter for tomotherapy respiratory tracking: A phantom study

Abstract

Background: Radixact Synchrony ® , a real-time motion tracking and compensating modality, is used for helical tomotherapy. Control parameters are used for the accurate application of irradiation. Radixact Synchrony ® uses the potential difference, which is an index of the accuracy of the prediction model of target motion and is represented by a statistical prediction of the 3D distance error. Although there are several reports on Radixact Synchrony ® , few have reported the appropriate settings of the potential difference threshold. Purpose: This study aims to determine the optimal threshold of the potential difference of Radixact Synchrony ® during respiratory tumor-motion-tracking irradiation. Methods: The relationship among the dosimetric accuracy, motion tracking accuracy,and control parameter was evaluated using a moving platform,a phantom with a basic respiratory model (the fourth power of a sinusoidal wave), and several irregular respiratory model waveforms. The dosimetric accuracy was evaluated by gamma analysis (3%, 1 mm, 10% dose threshold). The tracking accuracy was measured by the distance error of the difference between the tracked and driven positions of the phantom. The largest potential difference for 95% of treatment time was evaluated, and its correlation with the gamma-pass ratio and distance error was investigated. The optimal threshold of the potential difference was determined by receiver operating characteristic (ROC) analysis. Results: A linear correlation was identified between the potential difference and the gamma-pass ratio (R = -0.704). A linear correlation was also identified between the potential difference and distance error (R = 0.827). However, as the potential difference increased, it tended to underestimate the distance error. The ROC analysis revealed that the appropriate cutoff value of the potential difference was 3.05 mm. Conclusion:The irradiation accuracy with motion tracking by Radixact Synchrony ® could be predicted from the potential difference, and the threshold of the potential difference should be set to ∼3 mm.

Dosimetric evaluation in Helical TomoTherapy for lung SBRT using Monte Carlo‐based independent dose verification software

“…The latest TomoTherapy unit, Radixact, has equipped with Synchrony system, which enables to track tumors affected by respiratory motion. The Synchrony system in Radixact utilizes a model‐based approach to predict the target position based on the correlation between the internal target position obtained from two‐dimensional kV x‐ray radiographs and the motion of light‐emitting diode markers placed on the patient's chest 5 . In addition, the treatment time can be shortened due to the high dose rate (1000 MU/min) of Radixact compared with the older units 6 .…”

“…The Synchrony system in Radixact utilizes a model‐based approach to predict the target position based on the correlation between the internal target position obtained from two‐dimensional kV x‐ray radiographs and the motion of light‐emitting diode markers placed on the patient's chest. 5 In addition, the treatment time can be shortened due to the high dose rate (1000 MU/min) of Radixact compared with the older units. 6 Since shorter treatment times can reduce both patient motion and the baseline shift of the target during irradiation, 7 providing more accurate treatment.…”