Optimasi Hidroksipropil Metilselulosa dan Polivinil Pirolidon dalam Sediaan Mucoadhesive Buccal Film Diltiazem Hidroklorida

Abstract

Diltiazem HCl is a class of benzodiazepine calcium channel blockers used to treat angina pectoris, arrhythmias, and hypertension. Diltiazem HCl improves first-pass metabolism, a short half time of 3-5 hours, and bioavailability of diltiazem for oral administration of about 40%. Mucoadhesive buccal film diltiazem HCl releases the drug to the buccal mucosa, so the first pass metabolism can be avoided because of its absorption through the venous system that flows from the cheek. This study aimed to study HPMC polymers and polyvinyl pyrrolidone (PVP) polymers on swelling index, residence time, mucoadhesive strength of mucoadhesive buccal film diltiazem HCl, FTIR, and drug release. The prepared film was evaluated for swelling index, mucoadhesive strength, and mucoadhesive residence time. The optimal amount for HPMC was 35 mg, and PVP was 15 mg. The combination of polymers with this amount can produce a swelling index was 3,00, mucoadhesive strength was 41,87 gF, and mucoadhesive residence time was 330,66. FTIR test indicated that there was no interaction between active function clusters of Diltiazem HCl and other excipients. The release of the optimum formula in the 360th minute was about 97.847%, following in the zero-order release model and Higuchi.

Effect of alginate impression disinfection with sodium hypochlorite and castrol oil on Candida albicans counts and dimensional stability of the study model

“…24 The results of this study were in accordance with previous research from Sari, et al spraying 0.5% sodium hypochlorite on alginate impression resulting in dimensional changes that were still within tolerance limits. 29 This study was also in accordance with the study of Amelia, et al which showed there was a change in dimensional stability which was still within the tolerance limits of alginate impression after 0.5% sodium hypochlorite was sprayed. 9 Disinfection of alginate impression with 10% castor oil in group C2 showed an effect on the dimensional stability of the study model.…”

Formulation And Characterization Of Buccal Film Nanoemulsion Apigenin As Antidiabetic

“…Film Nanoemulsion Apigenin (Buccal Film Ne-APG) Organoleptic tests were carried out including visual observations such as color, clarity, and odor of the wet mixture and buccal film the resulting 22 .…”