Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology

Lestari, Wening; Setiyowati, Sri; Triningsih, Triningsih; Asyikin, Khoirunnisa Fauziah; Suharmadi, Suharmadi; Mujamilah, Mujamilah; Sulungbudi, Grace Tjungirai; Juliyanto, Sumandi

doi:10.22435/jki.v11i1.5071

jki

2022

DOI: 10.22435/jki.v11i1.5071

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Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology

Wening Lestari¹,

Sri Setiyowati²,

Triningsih Triningsih³

et al.

Abstract: The prevalence of cancer in Indonesia is increasing and various cancer treatments still have shortcomings, cancer recurrence still occurs. Lymphoscintigraphy is a method for detecting disorders of the lymphatic system, which are closely related to cancer cells. Human serum albumin nanocolloid as a lymphoscintigraphic agent consists of particles measuring

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2024

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Cited by 2 publications

References 17 publications

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The influence of sugar molecule type on the stability of lyophilized human serum albumin (HSA) nanocolloid kit

Haryuni,

Lestari,

Juliyanto

et al. 2024

J Radioanal Nucl Chem

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The influence of sugar molecule type on the stability of lyophilized human serum albumin (HSA) nanocolloid kit

Haryuni,

Lestari,

Juliyanto

et al. 2024

J Radioanal Nucl Chem

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Applying Box-Behnken Experimental Design for Optimization of Polyurethane Membrane Synthesis from Castor Oil (Ricinus communis L.) Based on Physical Performance

Hanum,

Safitri,

Idroes

et al. 2024

MSF

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The process of synthesizing polyurethane (PU) membranes typically involves linking together networks of polymers using organic materials like polyols and isocyanates. Subsequent investigations used additional inorganic substances within PU polymers to enhance the mechanical and thermal characteristics of membranes. In order to be used as a sensor matrix, the PU membrane needs to have certain good qualities and be able to firmly attach to ions. Hence, further refinement of the membrane is necessary in order to enhance these attributes. The PU membrane made from castor oil (Ricinus communis L.) was changed in this study by adding ĸ-carrageenan and D2EHPA. The composition of the membrane plays a crucial role in governing the creation of hard and soft segments within the membrane structure. The right membrane composition can be found by using Expert Version 13 software for process design. This software is based on the Response Surface Methodology and uses Box-Behnken Design. The primary aim of this study was to fabricate PU membranes utilizing natural resources while ensuring the attainment of desirable qualities. The R2 and PRESS values, which are very important for figuring out how important the physical performance response is, led to the choice of the quadratic model design as the best one. One of the experimental conditions was the use of 0.231 mg of D2EHPA, 1.241 mg of κ-carrageenan, and 3.840 g of acetone. The final mixture was predicted to have a visual scale value of 6.5 so that a membrane with the best physical properties in terms of strength and flexibility could be made. The composite-derived PU membrane has favorable physical performance. The findings of this study can serve as a foundational element for the advancement of PU membranes in a wide range of prospective applications.

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Optimasi Sintesa Nanokoloid Human Serum Albumin sebagai Agen Limfoskintigrafi Menggunakan Central Composite Design-Response Surface Methodology

Cited by 2 publications

References 17 publications

The influence of sugar molecule type on the stability of lyophilized human serum albumin (HSA) nanocolloid kit

The influence of sugar molecule type on the stability of lyophilized human serum albumin (HSA) nanocolloid kit

Applying Box-Behnken Experimental Design for Optimization of Polyurethane Membrane Synthesis from Castor Oil (<i>Ricinus</i><i> </i><i>communis</i><i> </i><i>L.</i>) Based on Physical Performance

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