Optimasi Sintesis Senyawa 1-(2,5-Dihidroksifenil)-(3-Piridin-2-IL) Propenon Sebagai Antiinflamasi Menggunakan Variasi Katalis NaOH

Wibowo, Andy Eko; Saputra, Andy Kurniawan; Susidarti, Ratna Asmah

doi:10.30595/pharmacy.v15i2.3698

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hasil ekstrak Auricularia nigricans diperoleh karateristik berwarna merah kehitaman, bau kurang kuat dan berbentuk padat dengan presentase rendemen sebesar 1,27%. Berdasarkan nilai rendemen termasuk dalam kategori sedikit [13].…”

Section: Hasil Dan Pembahasanunclassified

Antifungal Activity of Auricularia nigricans Methanol Extract against Candida parapsilosis using The Well Method

Dewi¹,

Yuliarni²

2023

Pharmasci

View full text Add to dashboard Cite

This study aims to determine the ability of the methanol extract of the fungus Auricularia nigricans to inhibit the growth of Candida parapsilosis. The extraction method used was maceration with the antifungal test method, namely the well method, the concentrations used were 0.2g/mL, 0.3g/mL, 0.4g/mL and 10% DMSO as a negative control. The results of the study showed that all concentrations used did not form inhibition zones. This result is included in the inactive category. So that Auricularia nigricans does not have antifungal activity against Candida parapsilosis.

show abstract

Section: Hasil Dan Pembahasanunclassified

Antifungal Activity of Auricularia nigricans Methanol Extract against Candida parapsilosis using The Well Method

Dewi¹,

Yuliarni²

2023

Pharmasci

View full text Add to dashboard Cite

show abstract

“…The yield is 65 %. The ideal yield is 100 %, if the yield is above 50 % it is called fair (Wibowo et al, 2018).…”

Section: Gude Bean Plant Determined At Stikes Tujuhmentioning

confidence: 99%

The Effectiveness of Flavonoids in Pigeon Pea (Cajanus cajan) as Inhibitors of α-Glucosidase Enzyme in Anti-diabetes

Ginaris,

Fauzah

2023

fitofarmaka JIF

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, due to relative and absolute insulin deficiency of the body. Acarbose is a drug that can be used to treat diabetes mellitus, especially type II diabetes mellitus. Type II diabetes mellitus is an endocrine disease that causes 95 % of deaths worldwide. Gude bean extract (Cajanus cajan) is one alternative to the use of natural anti-diabetic medicine, containing saponins, flavonoids, phenolics, and tannins. Flavonoids are antioxidant compounds that have a hypoglycemia effect in people with diabetes mellitus. This study aimed to test the inhibitory activity of alpha-glucosidase enzyme from gude bean extract. The enzyme α-glucosidase activity was quantified by measuring the quantity of para-nitrophenol generated at a wavelength of 405 nm. The inhibitory power of the α-glucosidase enzyme was seen from the IC50 value. Gude Bean Extract has the ability to inhibit the enzyme α-glucosidase resulting in an IC50 value of 69.67 ppm strong level activity. Gude Bean Extract has the ability to inhibit the enzyme α-glucosidase resulting in an IC50 value of 69.67 ppm with a strong strength level

show abstract

“…Test by Thin Layer Chromatography (TLC) The compound purity test was to determine the purity of the compound, 1-(2.5-dihydroxy phenyl) -3-pyridine-2il-propenone, which was obtained from the synthesis of pyridine-2carabaldehyde and 2.5 dihydroxyacetophenone 3 . The mobile phases used were chloroform, nhexane: ethanol (10:1), and n-hexane: ethanol (1:2), and the stationary phase used was Silica GF254.…”

Section: Puritymentioning

confidence: 99%

“…There have been many studies on new compounds whose efficacy is still not significantly known all this time. One of them is 1-(2.5-hydroxyphenyl)-(3pyridine-2-il)-propenone compound, a synthesis of chalcone derivative compounds that have several benefits in it 3 . Chalcone is one of the flavonoids which has a C6-C3-C6 framework.…”

Section: Introductionmentioning

confidence: 99%

“…The compound is obtained from synthesis using the microwave method. The synthesis is from 2.5-dihydroxyacetophenone and pyridine-2-carbaldehyde compound with K2CO3 catalyst without solvent, taking 4 minutes using a 140-watt microwave power 3 . Based on this background, this study aims to determine the antimicrobial activity of 1-(2.5-Dihydroxyphenyl)-(3-Piridin-2-Il)propenone compound, which was tested on Enterococcus faecalis and Escherichia coli by the well diffusion method.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Test of 1-(2.5-Dihydroxi Phenyl)-(3-Pyridine-2-Il) -Propanone Compound in Enterococcus Faecalis and Escherichia Coli Bacteria Using a Well Diffusion Method

Wibowo

Hatala

Edang

2021

JFAPS

View full text Add to dashboard Cite

1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound is a compound synthesized by reacting the pyridine-2-carbaldehyde and 2.5-dihydroxyacetophenone compound without solvent with K2CO3 (Potassium Carbonate) catalyst in the microwave. The 1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound is a chalcone derivative compound substituted by two hydroxy groups on ring A and has 2-pyridyl groups on ring B. Chalcone is a secondary metabolite compound from the flavonoid group, which has several activities as anti-platelet, anti-bacterial, immunomodulator, anti-hyperglycemic, and anti-inflammatory. This study aims to determine the antibacterial effect of 1-(2.5-dihydroxifenil)-(3-pyridine-2-il)-propenone compound against Enterococcus faecalis and Escherichia coli bacteria. This study used TLC (Thin Layer Chromatography) and Melting Point Test to analyze the purity of 1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound. Meanwhile, the test for antibacterial activity used a well diffusion method. Concentration variation for 1-(2.5-dihydroxifenyl)-(3-pyridine-2-il)-propenone compound as antibacterial in Escherichia coli were 0.25 mg/100 μl, 0.5 mg/200 μl, and 0.75 mg/300 μl. Meanwhile, the concentration variation for Enterococcus faecalis bacteria was 5%, 2.5%, 1.25% and was replicated three times. The results of the compound purity test using the melting point test and Thin Layer Chromatography (TCL) showed that the 1-(2.5-dihydroxy phenyl)-(3-pyridine-2-il)-propenone compound was pure. The results of the antibacterial activity test for 1-(2.5-dihydroxiphenyl)-(3-pyridine-2-il)-propenone compound showed no zone of inhibition at each test concentration. In conclusion, the 1-(2.5-dihydroxifenyl)-(3-pyridine-2-il)-propenone compound did not have an antibacterial effect on Enterococcus faecalis and Escherichia coli bacteria.

show abstract

Optimasi Sintesis Senyawa 1-(2,5-Dihidroksifenil)-(3-Piridin-2-IL) Propenon Sebagai Antiinflamasi Menggunakan Variasi Katalis NaOH

Cited by 3 publications

References 0 publications

Antifungal Activity of Auricularia nigricans Methanol Extract against Candida parapsilosis using The Well Method

Antifungal Activity of Auricularia nigricans Methanol Extract against Candida parapsilosis using The Well Method

The Effectiveness of Flavonoids in Pigeon Pea (Cajanus cajan) as Inhibitors of α-Glucosidase Enzyme in Anti-diabetes

Antimicrobial Test of 1-(2.5-Dihydroxi Phenyl)-(3-Pyridine-2-Il) -Propanone Compound in Enterococcus Faecalis and Escherichia Coli Bacteria Using a Well Diffusion Method

Contact Info

Product

Resources

About