Optimisation of reconstruction, volumetry and dosimetry for 99mTc-SPECT and 90Y-PET images: Towards reliable dose-volume histograms for selective internal radiation therapy with 90Y-microspheres

Bernardini, Michela; Thevenet, H. Slimani; Berthold, C.; Desbrée, Aurélie; Smadja, Corinne; Desiré, C.; Bianciardi, Marta; Ghazzar, N.

doi:10.1016/j.ejmp.2017.06.021

Cited by 3 publications

(5 citation statements)

References 35 publications

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“…However, assessment of accurate absorbed doses remains challenging in SIRT, due to the wealth of technical factors involved in the determination of accurate doses from scintigraphic volumes [ 35 ]. Among them, delineation of target volumes appears to be very critical as accurate volumes are a requirement for achieving reliable DVH with voxel-based dosimetry [ 19 ]. We evaluated two approaches for target delineation in SIRT.…”

Section: Discussionmentioning

confidence: 99%

“…Concerning overall survival (Table 7 ), threshold-based contours from 99m Tc-MAA scans were found to be significant predictive factors, whereas those from PET/CT imaging were not. 90 Y-microspheres PET/CT suffer from count-starving acquisitions and dedicated optimization of reconstruction parameters should be performed to obtain reliable results [ 19 , 37 , 38 ]. Our study uses two different generations of PET/CT systems and lacks of appropriate 90 Y optimization for the most recent scanner.…”

Section: Discussionmentioning

confidence: 99%

“…Controversial results have been reported in the literature depending on the type of image studied and the method used to assess the correlation between pre- and post-treatment dose metrics [ 10 , 15 , 36 , 40 , 41 ]. Apart from the technical gesture that has to be strictly identical, technical discrepancies (different kind of particles, injection flow) between the two procedures should explain the large variation of results reported [ 17 ] and harmonization of both images (SPECT and PET) should increase their similarity in the context of SIRT [ 19 , 42 ]. Moreover, as formulated by Lassman et al [ 43 ], the standardization of the SPECT/CT quantification is feasible and should improve results regarding such pre- and post-treatment comparison.…”

Section: Discussionmentioning

confidence: 99%

“…In both situations, as in all image-based dosimetric approaches, the choice of the contouring method may have a major influence on dose metrics [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy

et al. 2021

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Introduction The aim of this study was to evaluate the impact of the contouring methods on dose metrics and their predictive value on tumor control and survival, in both situations of pre-treatment and post-treatment dosimetry, for patients with advanced HCC treated with SIRT. Methods Forty-eight patients who underwent SIRT between 2012 and 2020 were retrospectively included in this study. Target volumes were delineated using two methods: MRI-based contours manually drawn by a radiologist and then registered on SPECT/CT and PET/CT via deformable registration (Pre-CMRI and Post-CMRI), 99mTc-MAA-SPECT and 90Y-microspheres-PET 10% threshold contouring (Pre-CSPECT and Post-CPET). The mean absorbed dose (Dm) and the minimal absorbed dose delivered to 70% of the tumor volume (D70) were evaluated with both contouring methods; the tumor-to-normal liver uptake ratio (TNR) was evaluated with MRI-based contours only. Tumor response was assessed using the mRECIST criteria on the follow-up MRIs. Results No significant differences were found for Dm and TNR between pre- and post-treatment. TNR evaluated with radiologic contours (Pre-CMRI and Post-CMRI) were predictive of tumor control at 6 months on pre- and post-treatment dosimetry (OR 5.9 and 7.1, respectively; p = 0.02 and 0.01). All dose metrics determined with both methods were predictive of overall survival (OS) on pre-treatment dosimetry, but only Dm with MRI-based contours was predictive of OS on post-treatment images with a median of 23 months for patients with a supramedian Dm versus 14 months for the others (p = 0.04). Conclusion In advanced HCC treated with SIRT, Dm and TNR determined with radiologic contours were predictive of tumor control and OS. This study shows that a rigorous clinical workflow (radiologic contours + registration on scintigraphic images) is feasible and should be prospectively considered for improving therapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…In both situations, as in all image-based dosimetric approaches, the choice of the contouring method may have a major influence on dose metrics [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy

et al. 2021

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“…The use of voxel models in MC radiation transport codes has contributed to the improvement of dose calculations. OEDIPE software based on MCNPX code was developed by the "French Institut de Radioprotection et de Sûreté Nucléaire" (IRSN), in order to investigate the body burden from internal contamination [41,42]. The GSF-GOLEM model was coupled with the FLUKA MC Radiation transport code for space dose assessment [43].…”

Section: Use Of Voxel Models / Monte Carlo Simulations In Nuclear Medicinementioning

confidence: 99%

Monte Carlo Simulation in Radionuclide Therapy Dosimetry

Argyrou

Lyra

2019

BJSTR

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Pre-treatment dosimetry in90Y-SIRT: Is it possible to optimise SPECT reconstruction parameters and calculation methods for accurate dosimetry?

Pham,

Presles,

Popoff

et al. 2023

Physica Medica

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Optimisation of reconstruction, volumetry and dosimetry for 99mTc-SPECT and 90Y-PET images: Towards reliable dose-volume histograms for selective internal radiation therapy with 90Y-microspheres

Cited by 3 publications

References 35 publications

Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy

Impact of contouring methods on pre-treatment and post-treatment dosimetry for the prediction of tumor control and survival in HCC patients treated with selective internal radiation therapy

Monte Carlo Simulation in Radionuclide Therapy Dosimetry

Pre-treatment dosimetry in90Y-SIRT: Is it possible to optimise SPECT reconstruction parameters and calculation methods for accurate dosimetry?

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