A large number of animal and clinical experiments show that 1,3‐diglyceride (1,3‐DAG) can significantly ameliorate obesity by improving blood lipid and glucose metabolism. After microencapsulation, it cannot only be used to prepare full‐nutrient food that meets the nutritional requirements of specific patients, but also improve the storage stability of oils. In this study, 1,3‐DAG microcapsules are prepared by using high‐amylose corn starch, resistant dextrin, and sodium caseinate as composite wall materials, and 1,3‐DAG with a purity of 80% as core material.Firstly, the water phase and oil phase are mixed evenly, and then the uniform emulsion is prepared by two steps of high‐speed shearing and high‐pressure homogenization. The prepared emulsion is desiccated by a spray dryer to prepare microcapsules. Taking the encapsulation rate as the judging criteria, five gradients of core and wall material are designed to obtain the optimal formula.The results show that when the amount of core material is 28% and the wall material is 70%, the encapsulation rate of 99.51% is the highest. The prepared 1,3‐DAG microcapsules have water content of 1.9% and solubility of 98.05%, the average particle size is 2.921 µm. The particles are uniform and stable, with fine color and texture, and a high oil content.