The combination of sliding/rolling motion can influence the degree of precision degradation of ball screw. Precision degradation modeling and factors analysis can reveal the evolution law of ball screw precision. This paper presents a precision degradation model for factors analysis influencing precision due to mixed sliding-rolling motion. The precision loss model was verified through the comparison of theoretical models and experimental tests. The precision degradation due to rolling motion between the ball and raceway accounted for 29.09% of the screw precision loss due to sliding motion. Additionally, the total precision degradation due to rolling motion accounted for 21.03% of the total sliding precision loss of the screw and nut, and 17.38% of the overall ball screw precision loss under mixed sliding-rolling motion. In addition, the effects of operating conditions and structural parameters on precision loss were analyzed. The sensitivity coefficients of factors influencing were used to quantitatively describe impact degree on precision degradation.