Optimization and characterization of polyhydroxybutyrate/lignin electro-spun scaffolds for tissue engineering applications

Mohammadalipour, Mohammad; Behzad, Tayebeh; Karbasi, Saeed; Mohammadalipour, Zahra

doi:10.1016/j.ijbiomac.2022.07.139

Cited by 39 publications

(15 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the uniformity has decreased again by reaching the injection rate of 0.30 mL/hr. The lack of continuous solution preparation or intermittent electrospinning could cause this increment 19 . Based on the ANOVA (Table 5), the injection rate has a significant effect on the uniformity of PLC fibers ( p ‐value of 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…The coefficient of variation (C.V.) was considered as a response for design:

C . V . = σ / μ

Where, σ refers to the standard deviation ( SD ), and μ is the mean of diameter 36,65 . It should be noted that the optimal conditions of PHB and PL electrospinning have been reported in our previous publication 19 . Moreover, PC solutions were also be able to electrospin at the same conditions with PHB 66 .…”

Section: Resultsmentioning

confidence: 99%

“…The lack of continuous solution preparation or intermittent electrospinning could cause this increment. 19 Based on the ANOVA (Table 5), the injection rate has a significant effect on the uniformity of PLC fibers (p-value of 0.001). Consequently, 0.5 mL/hr and 15 kV at distance of 15 cm were recognized as the optimal levels for PLC.…”

Section: Taguchi Designmentioning

confidence: 99%

“…Despite the careful selection of material, the solvent selection is often based on the previous literature or the trial‐and‐error method in most publications 15–17 . The mechanical properties investigation of electrospun scaffolds is also limited to the experimental examinations 18,19 . While theoretical studies of solubility and prediction of mechanical properties can turn a new page to estimate the final behavior of an electrospun fiber.…”

Section: Introductionmentioning

confidence: 99%

“…Figure 10 displayed two sharp peaks of PHB-based mats at 13.52 and 17.02 , corresponding to the (020), and (110) planes 19. According to Table10, not only is the crystallinity decreased by addition of lignin and CNF, but also crystal size has reduced.…”

mentioning

confidence: 98%

See 4 more Smart Citations

Theoretical and experimental investigation of solubility and Young's modulus models for polyhydroxybutyrate‐based electrospun scaffolds

Mohammadalipour

Behzad

Karbasi

et al. 2023

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Over the past decades, limited strategies have been developed to study nanomechanical properties. The in-depth study on the nanomechanical properties of electrospun scaffolds can provide better insights at greater scales. Atomic force microscopy (AFM) nanoindentation is an authoritative method that can characterize mechanical properties. In this research, theoretical solubility studies of polyhydroxybutyrate (PHB) in different solvents were initially carried out. Then, three series of PHB-based mats were prepared, including PHB/lignin, PHB/cellulose nanofiber (CNF), and PHB/lignin/CNF. The theoretical modulus of samples was studied from two different standpoints, through the use of nanoindentation on a single nanofiber. First, scaffolds were considered as a series of short fiber reinforced nanocomposites (NCs). In the second viewpoint, the geometrical structure of each scaffold was considered similar to an open-cell foam (OCF). Consequently, modeling outputs verified that among NC models, isotropic Halpin-Tsai presented plausible predictions with '93.36 to 99.77% accuracy. In addition, Tetrakaidecahedron indicated more accurate predictions among OCF models for the mats ('78.99 to 96.15% adaption). Indeed, the theoretical NC and OCF models were able to provide acceptable forecasts for the application range of electrospun fibers. Based on this, nanoscale investigation of mechanical properties can turn a new page to estimate the further application of mats.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The coefficient of variation (C.V.) was considered as a response for design: