Optimization and evaluation of gastroretentive ranitidine HCl microspheres by using design expert software

Hooda, Aashima; Nanda, Arun; Jain, Manish; Kumar, Vikash; Rathee, Permender

doi:10.1016/j.ijbiomac.2012.07.030

Cited by 78 publications

(38 citation statements)

References 25 publications

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“…In the development of pharmaceutical dosage forms, an important and crucial issue is to search an optimal formula for designing a product of desired quality by minimum trials within a short period [22]. Optimization by means of computer-aided statistical experimental design methodologies has been successfully applied in the literature for the development of various pharmaceutical dosage forms [23,24]. The statistical optimization technique encompasses designing a set of experiment that will reliably measure the response variables, fitting mathematical models to the data, conducting appropriate statistical tests to select best possible model, and determining the values of independent formulation variables to produce optimum response.…”

Section: Resultsmentioning

confidence: 99%

Formulation Optimization and Evaluation of Probiotic Lactobacillus sporogenes-Loaded Sodium Alginate with Carboxymethyl Cellulose Mucoadhesive Beads Using Design Expert Software

Solanki

Dm²

2016

Journal of Food Processing

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The present study deals with the formulation optimization of sodium carboxymethyl cellulose-alginate mucoadhesive beads containing probioticLactobacillus sporogenesthrough ionotropic gelation using 32factorial design. The effect of sodium carboxymethyl cellulose-alginate concentration on the probiotic entrapment efficiency (PEE, %), viability in simulated gastric fluid (log CFU/g), and mucoadhesion over 8 hr (%) was optimized. The optimized beads containing probioticLactobacillus sporogenesshowed entrapment efficiency of93.7±1.97%, viability of probiotic in simulated gastric fluid (log CFU/g) of 9.34, mucoadhesion of71.75±1.38%, and mean diameter of1.21±0.11 mm. The beads were also characterized by SEM, FTIR, and XRD. The swelling and degradation of these beads were influenced by pH of the test medium. Finally, stability tests performed at room temperature (25~28°C) highlighted a bacterial viability of about 91% and 86% after 1 and 2 months, respectively. The advantageous properties of probioticLactobacillus sporogenes-loaded mucoadhesive beads make them suitable for incorporation in functional food and/or pharmaceutical products.

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Section: Resultsmentioning

confidence: 99%

Formulation Optimization and Evaluation of Probiotic Lactobacillus sporogenes-Loaded Sodium Alginate with Carboxymethyl Cellulose Mucoadhesive Beads Using Design Expert Software

Solanki

Dm²

2016

Journal of Food Processing

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“…The optimization of different process parameters like -chitosan to tri polyphosphate weight ratio, acetic acid concentration, catechin hydrate concentration was done by mathematical modelling using Design-Expert® software with two level full factorial design [12]. Variations in chitosan to tri-poly phosphate weight ratio and acetic acid concentration during nanoparticle formation were evaluated for their effects on entrapment efficiency (EE) of drug.…”

Section: Preparation Of Chitosan Nanoparticles By Ionic Gelation Methodsmentioning

confidence: 99%

Synthesis, characterization and evaluation of antioxidant properties of catechin hydrate nanoparticles

Kaur

Rajput

Nag

et al. 2017

Journal of Drug Delivery Science and Technology

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A b s t r a c tContext: Catechin hydrate (CH), is an important phyto compound, reported to have potential therapeutic activity for prevention and treatment of various central nervous system (CNS) disorders. However, its therapeutic action is limited by their low oral bio and intestinal absorption, therefore, development of a targeted nanoparticle based carrier system which can overcome its physicochemical limitations and can enhance its biological activity is required. The objective of the pres formulation by ionic gelation method for catechin hydrate. Result and conclusion: After optimising the formulation by statistical tool, further, characterization results showed zeta average particle size of zeta potential of (range of 61. 8 loade profile and cytotoxicity analysis done on NB41A3 cell lines results exhibited the cell viability of 89.5 ± 0.25% in catechin loaded nanoparticles (CH NP's) whereas, indicating negligible toxicity in nanoparticle based formulation. The stability testing was done for CH NP's antioxidant activities estimated throug oxide ( higher and prolonged antioxidant activity in comparison with CH.

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“…Design matrices showing effect of independent variables on studied responses (dependent variables) are given in table no.2 and response surface plots are shown in Figure no. 1a-c. Optimization was done by modeling effect of independent variables on the responses by using quadratic mathematical model as shown in equation 1 and constraints on responses were maximum entrapment efficiency, maximum drug content and maximum mucoadhesion 21,22 .…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

Preparation of Sterculia foetida - pullulan based semi-interpenetrating polymer network gastroretentive microspheres of amoxicillin trihydrate and optimization by response surface methodology

Khan¹,

Hadke²

2020

tjps

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INTRODUCTION: In the current investigation a novel sterculia foetida and pullulan based semiinterpenetrating polymer network gastroretentive microsphere formulation was prepared by emulsion crosslinking method and optimized by central composite design. METHODS: The effect of amount of glutraldehyde, sterculia foetida and pullulan on percent drug entrapment efficiency (% EE), percent mucoadhesion at 12h and percent in vitro drug release at 12h (% Q12h) were optimized. The microspheres were also characterized by SEM, FTIR and DSC. RESULTS: The formulation containing 4%v/v Glutraldehyde, 8.28%w/v pullulan and 2.14% w/v sterculia foetida had 88.75± 1.18% EF, gave 80.43± 1.2% drug release in 12 h and 81.73± 1.50% mucoadhesion at 12 h was considered optimum and was used for in-vivo radiographic study. DISCUSSION AND CONCLUSION: From the study it was concluded that semiinterpenetrating polymer network microspheres loaded with amoxicillin trihydrate were successfully prepared using Sterculia foetida and pullulan gum. The prolong retention of microspheres in the stomach with sustained drug release could effectively act against the H-Pyroli reservoir in the stomach and improve the therapeutic effectiveness of amoxicillin trihydrate against H-Pyroli.

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Optimization and evaluation of gastroretentive ranitidine HCl microspheres by using design expert software

Cited by 78 publications

References 25 publications

Formulation Optimization and Evaluation of Probiotic Lactobacillus sporogenes-Loaded Sodium Alginate with Carboxymethyl Cellulose Mucoadhesive Beads Using Design Expert Software

Formulation Optimization and Evaluation of Probiotic Lactobacillus sporogenes-Loaded Sodium Alginate with Carboxymethyl Cellulose Mucoadhesive Beads Using Design Expert Software

Synthesis, characterization and evaluation of antioxidant properties of catechin hydrate nanoparticles

Preparation of Sterculia foetida - pullulan based semi-interpenetrating polymer network gastroretentive microspheres of amoxicillin trihydrate and optimization by response surface methodology

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