This research study focuses on the fatigue behavior of an aerospace elastoplastic cylindrical structural component with a hole subjected to cyclic mechanical loads. In the demanding operational environment of aerospace applications, the structural components, particularly those with stress concentrators like holes, experience cyclic loading conditions, leading to fatigue failure over time. The key objective of this study is to gain insights into this fatigue behavior, and to develop an optimized set of design and operational parameters that can enhance the fatigue performance of these components. Utilizing the robust finite element analysis capabilities of COMSOL Multiphysics, a comprehensive model of the elastoplastic cylindrical component is developed. The model captures the intricate effects of the hole, a typical stress raiser, on the fatigue performance under various cyclic mechanical loading conditions. A detailed fatigue analysis is then performed using this model, providing valuable insights into the fatigue life and failure patterns of the component. To enhance the fatigue performance, the Taguchi method, a statistical approach, is employed. This method helps to identify and optimize the key design and operational parameters influencing the fatigue life. The parameters are optimized based on their signal-to-noise ratio, with an aim to maximize the fatigue life and ensure the structural integrity of the component under operational cyclic loads. The findings of this research hold significant implications for the design and manufacturing of aerospace structural components, with potential benefits of improved safety, enhanced durability, and reduced maintenance requirements. However, the results' applicability might be limited by the complexity of real-world operational conditions and the assumptions made in the simulation model. Future studies can validate and enhance these results by incorporating more complex loading scenarios and real-world case studies.