It has always been important to study the development and improvement of the design of turbomachines, owing to the numerous uses of turbomachines and their high energy consumption. Accordingly, optimizing turbomachine performance is crucial for sustainable development. The design of impellers significantly affects the performance of centrifugal compressors. Numerous models and design methods proposed for this subject area, however, old and based on the 1D scheme. The present article developed a hybrid optimization model based on genetic algorithms (GA) and a 3D simulation of compressors to examine the certain parameters such as blade angle at leading and trailing edges and the starting point of splitter blades. New impeller design is proposed to optimize the base compressor. The contribution of this paper includes the automatic creation of generations for achieving the optimal design and designing splitter blades using a novel method. The present study concludes with presenting a new, more efficient, and stable design.