Optimization of a novel chelerythrine-loaded magnetic Fe3O4/chitosan alpha-ketoglutaric acid system and evaluation of its anti-tumour activities

Abstract

Fe3 O4 /KCTS-CHE exhibited effective anti-tumour activities against the HepG2 cells and induced cell apoptosis in HepG2 cells. Fe3 O4 /KCTS-CHE possess a high drug loading efficiency and entrapment efficiency, which are a new matrix for controlling release of drugs and a promising candidate for targeted drug delivery.