Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation

Developing Quantitative In Vitro–In Vivo Correlation for Fenofibrate Immediate-Release Formulations With the Biphasic Dissolution-Partition Test Method

“…4,5 Recently, the dissolution-partition systems, referred to as the biphasic test in this article, have been applied for characterization of both immediate-release and modified-release formulations. [6][7][8][9][10][11][12][13][14][15][16][17] The biphasic test involves both aqueous and organic phases and is designed to evaluate dissolution and precipitation of the drug formulations in aqueous phase under a nonsink condition accompanied by a simultaneous partition of the drug from the aqueous phase into the organic phase under a sink condition. The organic phase acts as an "absorptive compartment," and the amount of drug partitioned into this phase is dictated by the free drug concentration in the aqueous phase.…”

“…), discriminating capacity, and opportunity for in vitroein vivo relationship. [6][7][8][10][11][12][13][14][15][16] Amidon et al developed a mechanistic model to describe the drug transport phenomenon associated with the 2-phase dissolution system. 9 This approach assumes first-order absorption kinetics and a relatively high fraction absorbed in vivo (Fa).…”

Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems

“…Application of PGSS has been reported by several groups, including Rodrigues et el. who used hydrogenated palm oil for encapsulation of theophylline [79], Wang et al who encapsulated ibuprofen in myristic acid and tripalmitin [167], Pestieau et al who used Gelucire 50/13 to encapsulate fenofibrate [168], and Sao Pedro et al who produced curcumin-loaded tristearin/soy phosphatidylcholine particles using a small amount of organic solvents during the process [169]. Solid lipid particles produced in these reports were all in the >1000 nm range, indicating a process limitation of PGSS for lipid particles.…”

Hollow mesoporous silica as a high drug loading carrier for regulation insoluble drug release

“…Various approaches could be employed to improve the disadvantage of poorly water-soluble drugs, such as nanocrystal, solid dispersions, lipid-based formulation and so on (Carriere, 2015;Chen et al, 2016;Jahangiri et al, 2016;Maniruzzaman et al, 2015;Pestieau et al, 2015). Meanwhile, it has been a preferred approach to loaded water-insoluble drugs into mesoporous silica.…”