Uncertainty-based design optimization has been widely acknowledged as an advanced methodology to address competing objectives of aerospace vehicle design, such as reliability and robustness. Despite the usefulness of uncertainty-based design optimization, the computational burden associated with uncertainty propagation and analysis process still remains a major challenge of this field of study. The metamodeling is known as the most promising methodology for significantly reducing the computational cost of the uncertainty propagation process. On the other hand, the nonlinearity of the uncertainty-based design optimization problem's design space with multiple local optima reduces the accuracy and efficiency of the metamodels prediction. In this article, a novel metamodel management strategy, which controls the evolution during the optimization process, is proposed to alleviate these difficulties. For this purpose, a combination of improved Latin hypercube sampling and artificial neural networks are involved. The proposed strategy assesses the created metamodel accuracy and decides when a metamodel needs to be replaced with the real model. The metamodeling and metamodel management strategy are conspired to propose an augmented strategy for robust design optimization problems. The proposed strategy is applied to the multiobjective robust design optimization of an expendable launch vehicle. Finally, based on non-dominated sorting genetic algorithm-II, a compromise between optimality and robustness is illustrated through the Pareto frontier. Results illustrate that the proposed strategy could improve the computational efficiency, accuracy, and globality of optimizer convergence in uncertainty-based design optimization problems.