Today, gear designs with asymmetric tooth profiles offer essential solutions in reducing tooth root stresses of gears. Although numerical, analytical, and experimental studies are carried out to calculate the bending stresses in gears with asymmetric tooth profiles a standard or a simplified equation or empirical statement has not been encountered in the literature. In this study, a novel bending stress calculation procedure for gears with asymmetric tooth profiles is developed using both the DIN3990 standard and the finite element method. The bending stresses of gears with symmetrical profile were determined by the developed finite element model and was verified by comparing the results with the DIN 3990 standard. Using the verified finite element model, by changing the drive side pressure angle between 20° and 30° and the number of teeth between 18 and 100, 66 different cases were examined and the bending stresses in gears with asymmetric profile were determined. As a result of the analysis, a new asymmetric factor was derived. By adding the obtained asymmetric factor to the DIN 3390 formula, a new equation has been derived to be used in tooth bending stresses of gears with asymmetric profile. Thanks to this equation, designers will be able to calculate tooth bending stresses with high precision in gears with asymmetric tooth profile without the need for finite element analysis.