Optimization of chitosan-coated W/O/W multiple emulsion stabilized with Span 80 and Tween 80 using Box–Behnken design

Faghmous, Naima; Bouzid, Djallel; Boumaza, Marwa; Touati, Asma; Boyron, Olivier

doi:10.1080/01932691.2020.1774387

Cited by 9 publications

(10 citation statements)

References 60 publications

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“…One milliliter of each nanoemulsion sample was placed in the donor chamber, which was then covered with Parafilm. Samples were withdrawn from the receptor fluid in aliquots of 0.5 mL at regular intervals (1,2,4,8,12,16,24, and 48 h), filtered through a 0.45 mm membrane filter, and analyzed spectrophotometrically at λmax 274 nm for TEO content in skin leachables, to evaluate the permeation kinetics, and replenished by equivalent volumes of fresh PBS. The cumulative quantity of TEO permeated through the skin (Qn, mg/cm 2 ) was quantified using the following equation (Equation (3)) [31]:…”

Section: Permeability Experimentsmentioning

confidence: 99%

“…Emulsion droplets could be prevented from aggregating by generating mutual electrostatic and steric repulsive interactions between emulsion droplets coated with charged biopolymer [ 8 ]. The amazing characteristics and potentials of chitosan (CS) [ 9 , 10 ] as well as its capability to form extremely stable CS-coated secondary emulsion systems via electrostatic interactions with anionic surfactants or biomacromolecules (sodium dodecyl sulfate (SDS), sodium stearoyl, lecithin, ε-polylysine (EPL), poly(lactic-co-glycolic) acid (PLGA), and others) [ 11 , 12 , 13 ], make it a very attractive platform to formulate stable nanoemulsion delivery systems (NEDSs). However, chitosan’s limited aqueous solubility has limited its widespread use in the formulation of NEs.…”

Section: Introductionmentioning

confidence: 99%

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Upgrading the Transdermal Biomedical Capabilities of Thyme Essential Oil Nanoemulsions Using Amphiphilic Oligochitosan Vehicles

et al. 2022

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(1) Background: Thymus vulgaris L. (thyme) essential oil (TEO) has gained much attention because of its long history of medicinal usage. However, the lack of precise chemical profiling of the TEO and methods to optimize the bioactivity and delivery of its constituents has hampered its research on quality control and biological function; (2) Methods: The current study aimed to analyze the TEO’s chemical composition using the GC-MS method and identify its key components. Another objective of this work is to study the impact of the protective layer of amphiphilic oligochitosan (AOC) on the physicochemical stability and transdermal potentials of TEO multilayer nanoemulsions formulated by the incorporation of TEO, Tween80, lecithin (Lec), and AOC; (3) Results: The AOC protective layer significantly improved the stability of TEO-based NEs as revealed by the constancy of their physicochemical properties (particle size and zeta potential) during storage for a week. Excessive fine-tuning of thyme extract NEs and the AOC protective layer’s persistent positive charge have been contributed to the thyme extract’s improved anti-inflammatory, transdermal, and anti-melanoma potentials; (4) Conclusions: the AOC-coated NEs could offer novel multifunctional nanoplatforms for effective transdermal delivery of lipophilic bioactive materials.

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Section: Permeability Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Upgrading the Transdermal Biomedical Capabilities of Thyme Essential Oil Nanoemulsions Using Amphiphilic Oligochitosan Vehicles

et al. 2022

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“…The chitosan concentration may have affected its adsorption behavior on the silica surface (Li & Xia, 2011;Tiraferri et al, 2014). A recent study demonstrated the use of chitosan solution to coat the oil globules which entrapped insulin-containing internal aqueous phase due to polyelectrolyte complex formation with alginate present in the outer aqueous phase (Faghmous et al, 2020). This chitosan-coated W/O/W multiple emulsion seemed to be promising to be developed as a drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of the Stability of W/O/W Double Emulsion by Chitosan Modified Rice Husk Silica

Sapei¹,

Agustriyanto²,

Fitriani³

et al. 2022

IJTech

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The awareness of the need for healthy food continues to increase, hence, the demand for healthy food is also increasing. Water-in-oil-in-water (W/O/W) double emulsion can provide lowfat emulsion-based products due to a lower fraction of oil compared to the corresponding O/W emulsion. However, the stability of double emulsion has been quite tricky to be established due to the presence of two interfacial layers between oil and water. This research aims to study the use of biosilica in the form of rice husk ash (RHA) combined with both chitosan particles and chitosan solution to stabilize the interfacial layer between oil droplets and the outer aqueous phase. The concentrations of chitosan and biosilica, as well as pH of the outer aqueous phase in the acidic ranges, were varied to obtain W/O/W emulsion with higher stability. The primary emulsion was prepared by using the emulsifier mixtures of Tween 20 and Span 80. The resulting primary emulsion was subsequently dispersed into the outer aqueous phase, loaded with the combination of biosilica and chitosan particles/ solution. Emulsification processes were conducted using a rotorstator homogenizer. The resulting W/O/W emulsions with high stability of ~80-100% were obtained by using the combination of 0.5% biosilica and 1.25% chitosan particles/ 5.25% chitosan solution at the pH of 4. The use of biosilica and chitosan seemed promising to be applied in the manufacturing of healthier food emulsion-based products.

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“…Recently, multiple emulsions (MEs) have considerable promise for potentially broader utility, as a result of their internalized phase control of active ingredient release and complex particle templates, formed by dispersing one emulsion into another continuous phase either as water-in-oil-in-water (W/O/W) or as oil-in-water-in-oil (O/W/O). , The multilayer structure has been used successfully in diverse applications. , Li et al developted CMC W1 -NaCl W2 and Glu W1 -CMC W2 microemulsions and assessed the release properties of α-linolenic acid-loaded W 1 /O/W 2 MEs . In addition, MEs with an excellent encapsulation effect has been conducted to be combined with complex coacervation, solvent evaporation, membrane emulsification, and so forth to prepare different types of MCs. − Faghmous et al used the ionic gelation method to encapsulate MEs to establish insulin-loaded chitosan-coated W/O/W MEs, which possessed an initial and rapid release followed by slower release properties and effective controlled release of insulin …”

Section: Introductionmentioning

confidence: 99%

“…34−36 Faghmous et al used the ionic gelation method to encapsulate MEs to establish insulin-loaded chitosan-coated W/O/W MEs, which possessed an initial and rapid release followed by slower release properties and effective controlled release of insulin. 37 In this study, we first developed a multiple encapsulation strategy employing MEs and MCs. ME stability was improved and MC reaction process parameters were optimized.…”

Section: Introductionmentioning

confidence: 99%

Multi-Encapsulation Combination of O/W/O Emulsions with Polyurea Microcapsules for Controlled Release and Safe Application of Dimethyl Disulfide

Ren

Huang

Fang

et al. 2020

ACS Appl. Mater. Interfaces

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Dimethyl disulfide (DMDS), a promising alternative fumigant, has been highly desirable for excellent management of soil pests and diseases. However, high volatility and moderate toxicity of this sulfide limit its application. To address these issues, a novel controlled release formulation of DMDS was proposed employing multiple emulsions and polyurea microcapsules (DMDS@MEs-MCs). The successful combination of the two technologies was revealed by confocal laser scanning microscopy, scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared. According to the multiple encapsulation structure, the encapsulation efficiency decreased by only 3.13% after thermal storage, compared with a 15.21% decrease of microcapsules made with only a monolayer film. DMDS@MEs-MCs could effectively control the release of active ingredient, which increased applicator and environmental safety during application. Moreover, it could be facilely used by spraying and drip irrigation instead of a special fumigation device. The innovative formulation exhibited better control efficacy on soil pathogens (Fusarium spp. and Phytophthora spp.) and root-knot nematodes (Meloidogyne spp.) than DMDS technical concentration (DMDS TC). In addition, it did not inhibit seed germination after 10 days when the plastic film was removed from the fumigated soil. This method appears to be of broad interest for the development of safe and handy fumigant application.

show abstract

Optimization of chitosan-coated W/O/W multiple emulsion stabilized with Span 80 and Tween 80 using Box–Behnken design

Cited by 9 publications

References 60 publications

Upgrading the Transdermal Biomedical Capabilities of Thyme Essential Oil Nanoemulsions Using Amphiphilic Oligochitosan Vehicles

Upgrading the Transdermal Biomedical Capabilities of Thyme Essential Oil Nanoemulsions Using Amphiphilic Oligochitosan Vehicles

Enhancement of the Stability of W/O/W Double Emulsion by Chitosan Modified Rice Husk Silica

Multi-Encapsulation Combination of O/W/O Emulsions with Polyurea Microcapsules for Controlled Release and Safe Application of Dimethyl Disulfide

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