This experimental study explores and quantifies mixing characteristics associated with a gaseous round jet injected perpendicularly into cross-flow for a range of flow and injection conditions. The study utilizes acetone planar laser-induced fluorescence imaging to determine mixing metrics in both centreplane and cross-sectional planes of the jet, for a range of jet-to-cross-flow momentum flux ratios (2 J 41), density ratios (0.35 S 1.0) and injector configurations (flush nozzle, flush pipe and elevated nozzle), all at a fixed jet Reynolds number of 1900. For the majority of conditions explored, there is a direct correspondence between the nature of the jet's upstream shear layer instabilities and structure, as documented in detail in Getsinger et al. (J. Fluid Mech., vol. 760, 2014, pp. 342-367), and the jet's mixing characteristics, consistent with diffusion-dominated processes, but with a few notable exceptions. When quantified as a function of distance along the jet trajectory, mixing metrics for jets in cross-flow with an absolutely unstable upstream shear layer and relatively symmetric counter-rotating vortex pair cross-sectional structure tend to show better local molecular mixing than for jets with convectively unstable upstream shear layers and generally asymmetric cross-sectional structures. Yet the spatial evolution of mixing with downstream distance can be greater for a few specific convectively unstable conditions, apparently associated with the initiation and nature of shear layer rollup as a trigger for improved mixing. A notable exception to these trends concerns conditions where the equidensity jet in cross-flow has an upstream shear layer that is already absolutely unstable, and the jet density is then reduced in comparison with that of the cross-flow. Here, density ratios below unity tend to mix less well than for equidensity conditions, demonstrated to result from differences in the nature of higher-density cross-flow entrainment into lower-density shear layer vortices.