Optimization of Extraction Conditions for Active Components in<i>Hypericum perforatum</i>Using Response Surface Methodology

Liu, Frances F.; Ang, C. Y. W.; Springer, Dietmar

doi:10.1021/jf991086m

Cited by 99 publications

(74 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the decrease of degree of polymerization in direct sonication might be due to its stronger cavitation effect that leads to break fructan chain and subsequently decrease the average chain length. These results are in agreement with a study on the optimization of extraction conditions for active components from Hypericum perforatum and inulin from Jerusalem artichoke tubers using response surface methodology (Liu et al 2000;Lingyun et al 2007).…”

Section: Comparison Of Different Methods For Extraction Of Fructansupporting

confidence: 90%

Characterization of fructan extracted from Eremurus spectabilis tubers: a comparative study on different technical conditions

et al. 2014

View full text Add to dashboard Cite

The fructans, inulin and oligofructose, were known to possess many physiologic properties. In the present study, the Box-Behnken design was used to determine the optimum extraction conditions of fructan from Eremurus spectabilis root powder (Serish) with water extraction, direct and indirect ultrasound assisted extraction methods that gave the maximum yield. Sonication amplitude (20-100 %), sonication temperature (30-70°C) and sonication time (5-40 min) were considered variables of direct and indirect ultrasound extractions while for conventional extraction the following variables were water to solid ratio (30-50 v/w), temperature (40-90°C) and time (5-40 min). A second-order polynomial model was fitted to each response and the regression coefficients were determined using least square method. There was a good agreement between the experimental data and their predicted counterparts. In addition to establishing the difference of these extraction methods, the scanning electron microscopy, Fourier-transform infrared spectroscopy, zeta potential and particle size analysis have been shown to be useful tools to investigate, approximate and predict characteristics of extracted fructan. Moreover, comparison of conventional extraction, direct sonication extraction, indirect sonication extraction showed the indirect sonication extraction is a suitable method for fructan extraction.

show abstract

Section: Comparison Of Different Methods For Extraction Of Fructansupporting

confidence: 90%

Characterization of fructan extracted from Eremurus spectabilis tubers: a comparative study on different technical conditions

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Our results are in agreement with those of other authors who claim that phenolic compounds are often more soluble in organic solvents that are less polar than water. 14,15 Indeed, previous studies conducted on dry leaves of L. nobilis using ethanol and water as solvents reported higher phenolic contents in ethanolic extracts than in aqueous ones (132 mg GAE per g and 62 mg GAE per g, respectively). 7 More recently, Muñiz-Márquez et al described a phenolic content of 17.32 mg g −1 of L. nobilis (from Mexico), by using ultrasound-assisted extraction (35% ethanol) for 40 min.…”

Section: Phytochemical Contentsmentioning

confidence: 99%

Monomeric and oligomeric flavan-3-ols and antioxidant activity of leaves from different Laurus sp.

et al. 2015

View full text Add to dashboard Cite

The phenolic profile and antioxidant activity of three endemic Laurus sp. from Portugal were analysed. Dried leaves of L. nobilis L., L. azorica (Seub.) Franco, and L. novocanariensis Rivas Mart., Lousã, Fern. Prieto, E. Días, J. C. Costa & C. Aguiar, collected in the mainland and in the Azores and Madeira archipela-gos, respectively, were used to prepare different extracts (aqueous, ethanolic and hydroalcoholic). They were studied regarding their DPPH • scavenging activity, total phenolic and flavonoid contents, and the main phenolic compounds were identified by HPLC-DAD-ESI-MS/MS. Total flavonoid contents were 30.1, 46.3, and 36.7 mg of epicatechin equivalents per g of sample (dry weight) for L. nobilis, L. azorica and L. novocanariensis, respectively. Epicatechin was the major compound, representing ∼12.1% of total flavan-3-ols in L. nobilis, ∼25.6% in L. azorica, and ∼19.9% in L. novocanariensis. Although all samples presented a similar phenolic profile, significant differences were observed in their total contents and anti-oxidant activity.

show abstract

“…Response surface modelling is a valuable tool for optimization of several processes such as, fermentation, hydrolysis and chemical reactions (Baek and Cadwallader, 1995;Diniz and Martin, 1996;Ibanoglu et al, 1998;Liu et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology

Xuan

Ruan

et al. 2005

J Zheijang Univ Sci B

View full text Add to dashboard Cite

Angiotensin I-converting enzyme (ACE) inhibitory peptides have been shown to have antihypertensive effects and have been utilized for physiologically functional foods and pharmaceuticals. The ACE inhibitory ability of a hydrolysate is determined by its peptide composition. However, the peptide composition of a hydrolysate depends on proteolytic enzyme and the hydrolysis conditions. In this study, the effect of process conditions on the ACE inhibitory activity of rice dregs hydrolyzed with a trypsin was investigated systematically using response surface methodology. It was shown that the ACE inhibitory activity of rice dregs hydrolysates could be controlled by regulation of five process conditions. Hydrolysis conditions for optimal ACE inhibition were defined using the response surface model of fractional factorial design (FFD), steepest ascent design, and central composite design (CCD).

show abstract

Optimization of Extraction Conditions for Active Components inHypericum perforatumUsing Response Surface Methodology

Cited by 99 publications

References 15 publications

Characterization of fructan extracted from Eremurus spectabilis tubers: a comparative study on different technical conditions

Characterization of fructan extracted from Eremurus spectabilis tubers: a comparative study on different technical conditions

Monomeric and oligomeric flavan-3-ols and antioxidant activity of leaves from different Laurus sp.

Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology

Contact Info

Product

Resources

About