Optimization of gas chromatographic method for the enantioseparation of arylpropionic non-steroidal anti-inflammatory drug methyl esters

Enantiomers and Their Resolution

“…Alanina, prolina, serina, asparagine, glutamine, lisine, ornitina Chirasil-l-Val capillary columns Helium [95] Obuprofen, fenoprofen and ketoprofen methyl esters Heptakis-(2,3-di-Omethyl-6-O-t-butyldimethyl-silyl)-β-cyclodextrin Hydrogen [96] Chiral epoxides Cyclodextrin derivatives Nitrogen [97] α-amino acids Modified Linear Dextrins Hydrogen [98] Methyl branched compounds 2,3-Di-O-methoxymethyl-6-O-tertbutyldimethylsilyl-γ-cyclodextrin Hydrogen [99] Hydrocarbons, underivatized alcohols, ketones, and proteinogenic amino acid derivatives Citronellal, camphor, alanine, leucine, valine, isoleucine, 1-phenyl-1,2-ethandiol, phenylsuccinic acid, and 1-phenyl-ethanol Chiral Metal-Organic Frameworks Nitrogen [111] Cathinone-and amphetamine-related designer drugs Trifluoroacetyl-l-prolyl chloride Helium [112] Galaxolide, tonalide, phantolide, traseolide and cashmeran Chiral heptakis(2,3-di-O-methyl-6-O-t-butyl dimethylsilyl)-cyclodextrin Helium [113] Citronellal, 1-phenyl-1,2-ethandiol, 1-Phenyl-ethanol, 2-amino-1-butanol, limonene, methionine, proline Porous Chiral Metal-Organic Framework Nitrogen [114] 2-hexanol, linalool, citronellal, methyl l-b-hydroxyisobutyrate, limonene, rose oxide, dihydrocarvyl acetate, menthol, valine, and leucine Metal-Organic Framework on a Chiral Cyclodextrin Nitrogen [115] 30 amino acids Press-Tight© connected Varian-Chrompack Chirasil-l-Val Helium [116] 5.3.2. SFC-Supercritical Fluid Chromatography Supercritical fluids display transient properties between liquid and gas phases; therefore SFC works as an intermediate between GC and LC [117].…”

Chiral Separations

“…A GC/ MS method using a chiral capillary column was reported for the separation of the enantiomers of ibuprofen from tablets (112). An optimized chiral GC method for the enantioseparation of ibuprofen, fenoprofen, and ketoprofen methyl esters mixture used heptakis-(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-β-CD as the CSP (113). Chiral PCBs in food samples were enantioseparated on commercially available chiral capillary β-CD columns by means of heart-cut multidimensional GC and two-dimensional GC (114).…”

Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column

“…Several methods have been reported for analyses of NSAIDs in various matrices using capillary zone electrophoresis [5], gas chromatography (GC) [6], GC-mass spectrometry (GC-MS) [7,8], liquid chromatography (LC) [9][10][11][12][13][14][15][16], LC-MS, and LC-MS-MS [17][18][19][20][21][22]. Most of these techniques employed extraction methods such as liquid-liquid extraction (LLE) [5,7,9,[11][12][13]19,22], solidphase extraction (SPE) [8,10,17,18,20], and solid-phase microextraction [15,16] to remove impurities contained in human body fl uid samples.…”