Optimization of high‐resolution USPIO magnetic resonance imaging at 4.7 T using novel phantom with minimal structural interference

Antell, Henrik; Numminen, Jussi; Abo‐Ramadan, Usama; Niemelä, Mika; Hernesniemi, Juha; Kangasniemi, Marko

doi:10.1002/jmri.22181

Cited by 4 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…USPIOs exhibit a T1 shortening effect owing to the reduction in the volume magnetic anisotropy and spin disorders on the surface of the nanoparticles [12]. In addition, the dextran coating of USPIOs prevents endocytosis by macrophages, permitting a long plasma half-life [13,14]. With these properties, the possibility of using USPIOs as an alternative blood pool MR contrast agent has emerged.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Characteristics of New, Uniform, Extremely Small Iron-Based Nanoparticles as T1 Contrast Agents for MRI

Lee

Park

et al. 2021

Korean J Radiol

View full text Add to dashboard Cite

Objective:The purpose of this study was to evaluate the magnetic resonance (MR) characteristics and applicability of new, uniform, extremely small iron-based nanoparticles (ESIONs) with 3-4-nm iron cores using contrast-enhanced magnetic resonance angiography (MRA). Materials and Methods: Seven types of ESIONs were used in phantom and animal experiments with 1.5T, 3T, and 4.7T scanners. The MR characteristics of the ESIONs were evaluated via phantom experiments. With the ESIONs selected by the phantom experiments, animal experiments were performed on eight rabbits. In the animal experiments, the in vivo kinetics and enhancement effect of the ESIONs were evaluated using half-diluted and non-diluted ESIONs. The between-group differences were assessed using a linear mixed model. A commercially available gadolinium-based contrast agent (GBCA) was used as a control. Results: All ESIONs showed a good T1 shortening effect and were applicable for MRA at 1.5T and 3T. The relaxivity ratio of the ESIONs increased with increasing magnetic field strength. In the animal experiments, the ESIONs showed peak signal intensity on the first-pass images and persistent vascular enhancement until 90 minutes. On the 1-week follow-up images, the ESIONs were nearly washed out from the vascular structures and organs. The peak signal intensity on the first-pass images showed no significant difference between the non-diluted ESIONs with 3-mm iron cores and GBCA (p = 1.000). On the 10-minutes post-contrast images, the non-diluted ESIONs showed a significantly higher signal intensity than did the GBCA (p < 0.001). Conclusion:In the phantom experiments, the ESIONs with 3-4-nm iron oxide cores showed a good T1 shortening effect at 1.5T and 3T. In the animal experiments, the ESIONs with 3-nm iron cores showed comparable enhancement on the first-pass images and superior enhancement effect on the delayed images compared to the commercially available GBCA at 3T.

show abstract

Section: Introductionmentioning

confidence: 99%

Investigation of the Characteristics of New, Uniform, Extremely Small Iron-Based Nanoparticles as T1 Contrast Agents for MRI

Lee

Park

et al. 2021

Korean J Radiol

View full text Add to dashboard Cite

show abstract

Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging

Prévot

Kauss

Lorenzato

et al. 2017

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Dallet

Stanicki

Voisin

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r2 relaxivities (100 mM−1 s−1) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g−1 Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.

show abstract

Optimization of high‐resolution USPIO magnetic resonance imaging at 4.7 T using novel phantom with minimal structural interference

Cited by 4 publications

References 38 publications

Investigation of the Characteristics of New, Uniform, Extremely Small Iron-Based Nanoparticles as T1 Contrast Agents for MRI

Investigation of the Characteristics of New, Uniform, Extremely Small Iron-Based Nanoparticles as T1 Contrast Agents for MRI

Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging

Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

Contact Info

Product

Resources

About