The Antarctic region harbors abundant natural resources that constitute a common heritage site for humankind. However, given climate change and global resource scarcity, natural resource management has emerged as a pivotal issue in Antarctic governance. Assessing the value of natural resources is fundamental and crucial for ensuring their sustainable utilization and conservation. This study attempted to promote decision-makers’ understanding of the Antarctic using nature’s contribution to people (NCP) and provide an evaluation of the value of natural resources in the Antarctic, thereby contributing to sustainable global development. It developed a conceptual framework for evaluating natural resource values in the NCP, which includes scope delimitation, type identification, and value assessment. Economic value assessments were conducted for key NCPs in Antarctica. Based on existing biological, physical, and economic data, our initial estimates indicate that the economic value of the realized NCP is approximately 2.46 trillion CNY, with regulating NCP accounting for roughly 70% of the total value. If the potential NCP in the Antarctic were realized at foreseeable scientific and technological levels, the total economic value would reach approximately 105.62 trillion CNY. Regulating NCP accounted for most of the total value, but material NCP accounted for more than 20%. Overall, the development of natural resources and environmental protection are two sides of the same coin in the Antarctic, and there may be trade-offs between different NCPs. With increasing human activity, many NCP may be lost in the Antarctic region. This study develops a new perspective on the valuation of nature’s contributions to the Antarctic. The evaluation results can provide scientific evidence for decision-making and management of the development and utilization of natural resources in the Antarctic.