Optimization of maghemite-loaded PLGA nanospheres for biomedical applications

Silva, Marcela Fernandes; Hechenleitner, Ana Adelina Winkler; Oliveira, Daniela Martins Fernandes de; Agüeros, Maite; Peñalva, Rebeca; Irache, Juan M.; Pineda, Edgardo Alfonso Gómez

doi:10.1016/j.ejps.2013.04.006

Cited by 25 publications

(14 citation statements)

References 59 publications

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“…These results indicated that maghemite was totally encapsulated in the resulting PCL nanocapsules. These findings are in agreement with previous determinations described previously [13,20] who have been working with iron oxide-PLGA composite particles. The electrokinetic properties of Mag loaded PCL nanocapsules are in agreement with those of pure PCL, as one would predict in case of an optimum coverage [41].…”

supporting

confidence: 93%

“…sults reported by other research groups [7,20] and they would be related with the hydrophilic nature of the surface of maghemite nanoparticles. This fact would be the reason for the moderate retention of these nanoparticles, which would migrate to the outer aqueous phase during the emulsification step of the preparative process of PCL carriers.…”

supporting

confidence: 52%

“…[20] Aqueous PVA solution (10% w/v) and saturated ferric nitrate solution were mixed at metallic ion/monomer unit ratio of 1:18. The mixture was maintained at room temperature under stirring for 2 h and after heated under magnetic stirring until total water evaporation.…”

Section: Synthesis Of Maghemite Nanoparticles (Mag)mentioning

confidence: 99%

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Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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Iron oxide nanoparticles (ION) have been studied for essential applications, like detection of biological constituents (virus, bacterials, cell, nucleic acids, protein, enzyme, etc.), magnetic bioseparation and clinic therapy and diagnosis (such as MRI magnetic fluid and hyperthermia). In this work, γ-Fe 2 O 3 has been synthetized by a adapted sol-gel method and entraped in poly ε-caprolactone (PCL) nanocapsules. The superparamagnetic nanocapsules have been formulated by double emulsion evaporation method. Some variables affecting the polydispersity index, zeta potential surface and size of nanocapsules were studied aiming optimize the formulation process of maghemite-loaded PCL nanocapsules. The following parameters were selected: sonication time, PCL concentration in organic phase, PVA concentration in external aqueous phase and maghemite/PCL weight ratio. Under these experimental conditions, the resulting nanocapsules displayed a mean size of about 346 nm and a maghemite content of about 7.5 µg/mg of nanocapsules and superparamagnetic behaviour at room temperature.

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supporting

confidence: 93%

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confidence: 52%

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Superparamagnetic maghemite loaded poly (ε- caprolactone) nanocapsules : characterization and synthesis optimization

et al. 2014

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“…The preparation of the PLGA magnetic nanospheres (with maghemite entrapment) (PLGA-Mag) or PLGA nanospheres (hollow spheres) (PLGA-H) was performed by using single emulsion method 4 . The maghemite nanoparticles were dispersed in organic solvent by sonication for 1 min.…”

Section: Preparation Of Maghemite Loaded-plgamentioning

confidence: 99%

“…Magnetic nanoparticles like iron oxides are of great interest for researchers from a wide range of disciplines, including magnetic fluids, catalysis, biotechnology/biomedicine, magnetic resonance imaging, data storage, and environmental remediation [1][2][3][4] . While a number of suitable methods have been developed for the synthesis of magnetic nanoparticles of various different compositions, successful application of such magnetic nanoparticles in the areas listed above is highly dependent on the stability of the particles under a range of different conditions.…”

Section: Introductionmentioning

confidence: 99%

Study of Thermal Degradation of PLGA, PLGA Nanospheres and PLGA/Maghemite Superparamagnetic Nanospheres

et al. 2015

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Poly(glycolide-co-lactide) (PLGA) nanospheres containing magnetic materials have been extensively studied because of its biomedical applications. Therefore, it is very important to know thermal properties of these materials in addition to other physical properties. Thermal degradation activation energy (E α ) of PLGA nanospheres with maghemite entrapment (PLGA-Mag), PLGA nanospheres (hollow spheres) (PLGA-H) obtained by an emulsion method and unprocessed PLGA (PLGA-R) were calculated by isoconversional Vyazovkin method based on data of TG analysis in order to evaluate modifications in thermal behavior caused by nanospheres obtainment process or by maghemite entrapment. Both hydrodynamic diameter in the range of 200-250 nm and polydispersity index lower than 0.3 are considered satisfactory. Thermal degradation of PLGA-R begins at higher temperatures than those of PLGA-H and PLGA-Mag, but processed samples presented increase in thermal stability, which was greater before processing by emulsion and in the presence of the magnetic materials. PLGA-Mag presents superparamagnetic behavior at room temperature.

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