Optimization of microwave assisted extraction of  Morus nigra  L. fruits maximizing tyrosinase inhibitory activity with isolation of bioactive constituents

Koyu, Halil; Kazan, Aslihan; Demir, Serdar; Haznedaroğlu, Mehmet Zeki; Yeşil-Çeliktaş, Özlem

doi:10.1016/j.foodchem.2017.12.049

Cited by 57 publications

(44 citation statements)

References 33 publications

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“…In another research, Sugimoto et al. have investigated a comparison of inhibitory effects of alpha-arbutin and arbutin with human tyrosinase and they have found α-arbutin is stronger than arbutin 132 .…”

Section: Tyrosinase Inhibitionmentioning

confidence: 99%

A comprehensive review on tyrosinase inhibitors

Zolghadri

Bahrami

Khan³

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

777

471

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Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose, many natural, semi-synthetic and synthetic inhibitors have been developed by different screening methods to date. This review has focused on the tyrosinase inhibitors discovered from all sources and biochemically characterised in the last four decades.

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Section: Tyrosinase Inhibitionmentioning

confidence: 99%

A comprehensive review on tyrosinase inhibitors

Zolghadri

Bahrami

Khan³

et al. 2019

Journal of Enzyme Inhibition and Medicinal Chemistry

777

471

View full text Add to dashboard Cite

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“…Koyu et al [41] tested the microwave-assisted extraction of fresh fruits of M. nigra in variable conditions for optimizing and maximizing tyrosinase inhibitory activity. Consequently, the highest tyrosinase inhibitory activity (IC 50 value 1.44 mg/mL) was observed in the optimum microwave extraction system yielding the highest amount of anthocyanin content (13.28 mg/g cyanidin-3-glucoside equivalent), suggesting the important potential of anthocyanins on tyrosinase inhibition.…”

Section: Anti-melanogenic (Skin-whitening) Activitymentioning

confidence: 99%

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

2019

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Mulberry plants belonging to the Moraceae family have been grown for the purpose of being the nutrient source for silk worm and raw materials for the preparation of jams, marmalades, vinegars, juices, wines, and cosmetics. Morus nigra L. (black mulberry) is native to Southwestern Asia, and it has been used as a traditional herbal medicine for animals and humans. In this article, recent research progress on various biological and pharmacological properties of extracts, fractions, and isolated active constituents from different parts of M. nigra are reviewed. M. nigra exhibited a wide-spectrum of biological and pharmacological therapeutic effects including antinociceptive, anti-inflammatory, antimicrobial, anti-melanogenic, antidiabetic, anti-obesity, anti-hyperlipidemic, and anticancer activities. M. nigra also showed protective effects against various human organs and systems, mainly based on its antioxidant capacity. These findings strongly suggest that M. nigra can be used as a promising nutraceutical resource to control and prevent various chronic diseases.

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“…Many new extraction technologies have been developed to separate flavonoids from plants, such as ultrasound-assisted extraction (UAE) [ 25 , 31 ], microwave-assisted extraction (MAE) [ 29 ], and supercritical extraction [ 34 ]. Supercritical extraction (including subcritical water extraction, supercritical fluid extraction, pressurized fluid extraction, and accelerated solvent extraction) was proved to be a suitable technique for isolation of flavonoids [ 35 , 36 ]. Ultrasound-assisted extraction and MAE are more known to be a fast and efficient method for the extraction of flavonoids from plants.…”

Section: Introductionmentioning

confidence: 99%

Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities

Shang

Tan

et al. 2018

Molecules

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Deep eutectic solvents (DESs) are commonly employed as environmentally-friendly solvents in numerous chemical applications owing to their unique physicochemical properties. In this study, a novel and environmentally-friendly extraction method based on ultrasound assisted-deep eutectic solvent extraction (UAE-DES) was investigated for the extraction of flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus) leaves, and the antioxidant activities of these flavonoids were evaluated. Nine different DES systems based on either two or three components were tested, and the choline chloride/1,4–butanediol system (1:5 molar ratio) was selected as the optimal system for maximizing the flavonoid extraction yields. Other extraction conditions required to achieve the maximum flavonoid extraction yields from the leaves of C. paliurus were as follows: DES water content (v/v), 30%; extraction time, 30 min; temperature, 60 °C; and solid-liquid ratio, 20 mg/mL. Liquid chromatography-mass spectrometry allowed the detection of five flavonoids in the extract, namely kaempferol-7-O-α-l-rhamnoside, kaempferol, quercetin, quercetin-3-O-β-d-glucuronide, and kaempferol-3-O-β-d-glucuronide. In vitro antioxidant tests revealed that the flavonoid-containing extract exhibited strong DPPH and ABTS radical-scavenging abilities. Results indicate that UAE-DES is a suitable approach for the selective extraction of flavonoids from C. paliurus leaves, and DESs can be employed as sustainable extraction media for other bioactive compounds.

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Optimization of microwave assisted extraction of Morus nigra L. fruits maximizing tyrosinase inhibitory activity with isolation of bioactive constituents

Cited by 57 publications

References 33 publications

A comprehensive review on tyrosinase inhibitors

A comprehensive review on tyrosinase inhibitors

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource

Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities

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