Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities

Shang, Xingfu; Tan, Jia‐Neng; Du, Yongmei; Liu, Xinmin; Zhang, Zhongfeng

doi:10.3390/molecules23092110

Cited by 54 publications

(23 citation statements)

References 39 publications

(49 reference statements)

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“…The traditional extraction processes using organic solvents often induces toxicity and involves the use of flammable, explosive, and poorly biodegradable substances. Therefore, it is necessary to find a green extraction technology for such purposes [14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

et al. 2019

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In this study, deep eutectic solvents (DESs) were used for the ultrasound-assisted extraction (UAE) of valuable bioactive compounds from Chinese wild rice (Zizania spp.). To this end, 7 different choline chloride (CC)-based DESs were tested as green extraction solvents. Choline chloride/1,4-butanediol (DES-2) exhibited the best extraction efficiency in terms of parameters such as the total flavonoid content (TFC), total phenolic content (TPC), and free radical scavenging capacity (DPPH● and ABTS●+). Subsequently, the UAE procedure using 76.6% DES-2 was also optimized: An extraction temperature of 51.2 °C and a solid–liquid ratio of 37.0 mg/mL were considered optimal by a Box–Behnken experiment. The optimized extraction procedure proved efficient for the extraction of 9 phenolic and 3 flavonoid compounds from Chinese wild rice as determined by quantification based on ultra-performance liquid chromatography–triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS). This work, thus, demonstrates the possibility of customizing green solvents that offer greater extraction capacity than that of organic solvents.

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Section: Introductionmentioning

confidence: 99%

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

et al. 2019

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“…Historically, extraction and separation of flavonoids from C. paliurus using a traditional method with organic solvent and chromatography, which brings derivative problems such as waste of labor, consumption of resource, harm to human health and environmental pollution etc. Environment‐friendly methods with new technique were investigated recently years, including ultrasound assisted‐deep eutectic solvent extraction (UAE‐DES) (Shang, Tan, Du, Liu, & Zhang, 2018 and microwave irradiation (Xie et al, 2015). Aqueous two‐phase system (ATPS) is a new liquid‐liquid fraction technique that has been extensively applied in the separation and purification of natural products including phenols (Xu, Qiu, Ren, Ju, & Jia, 2017), flavonoids (He, Li, Wang, & Deng, 2016), alkloid (Zhou et al, 2018), proteins (Chang, Show, Lan, Tsai, & Huang, 2018), genetic material (Nazer, Dehghani, & Goliaei, 2017), polysaccharide (Li et al, 2017)and secondary metabolites etc.…”

Section: Introductionmentioning

confidence: 99%

“…Response surface methodology (RSM) has been applied for process optimization (Liu, 2012; Yang et al, 2007). RSM is a collection of statistical techniques and mathematical models that are used to define the relationship between the variables and the response (Shang et al, 2018). RSM is use of developin.g, improving and optimizing processes as well as is used to examine the relationship between one or more response variables and a set of quantitative experimental variables or factors.…”

Section: Introductionmentioning

confidence: 99%

Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) leaves using ethanol/salt aqueous two‐phase system coupled with ultrasonic

Shen

Liu

Tang

et al. 2020

J Food Process Preserv

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An aqueous two phase system (ATPS) coupled with ultrasonic was employed to extract flavonoids from Cyclocarya paliurus (Batalin) Iljinskaja leaves first time. The optimal conditions were determined by Response Surface Methodology(RSM) of ethanol concentration 33%; salt concentration 15%; extraction time 52 min; liquid‐solid ratio 33:1, while the flavonoids extraction yield obtained the maximum of 3.00 ± 0.1%. The antioxidant activity of flavonoids was evaluated by vitro antioxidant assays under the optimal conditions, which indicated that the extract has strong DPPH, ABTS + and superoxide anion radical‐scavenging activity (IC50 value of 0.0013 mg/ml, 0.0296 mg/ml and 0.126 mg/ml) which were close to and even better than Vc (extremely close to 0, 0.0291 mg/ml and 0.433 mg/ml). The study showed that the ATPS‐ultrasonic was a commendable approach for the extraction of flavonoids from C. paliurus and the flavonoids may serve as new natural antioxidant for functional food ingredients and additives. Practical applications In this study, ethanol and inorganic salt are selected as the extraction and separation solvent, which is simpler than the traditional method, environmental friendly, while reducing the process cost, and has great application value. Furthermore, through the analysis of the extraction components of the edible plant Cyclocarya paliurus, it was found that the flavonoids contained in C paliurus had antioxidant activity close to vitamin C. Combined with the above research, C. paliurus has the potential to develop into functional food and additives with antioxidant function.

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“…The tailor-made DESs have tremendous potential for efficient and simultaneous extraction and separation of compounds which have obvious differences in nature [16]. Recently, many reports have shown that tailor-made DESs were successfully employed in the extraction and separation of different kinds of bioactive compounds, such as phenolic acids, flavonoids, alkaloids, and saponins, from various plant materials [17,18,19,20,21,22]. Nonetheless, most of the research used tailor-made binary DESs as extraction solvents for bioactive compound extractions, the number of reports on the application of tailor-made ternary DESs for extraction is still limited, and the efficiency of DESs for extraction of bioactive phenolic acids from AL still remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

Duan

Zhang

et al. 2019

Molecules

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The Artemisia argyi leaf (AL) has been used as a traditional medicine and food supplement in China and other Asian countries for hundreds of years. Phytochemical studies disclosed that AL contains various bioactive constituents. Among bioactive constituents, phenolic acids have been recognized as the main active compounds in AL. To the best of our knowledge, no research has been focused on extraction method for the bioactive phenolic acids from AL. Nowadays, deep eutectic solvents (DESs) are emerging as a new type of green and sustainable solvent for efficient extraction of bioactive compounds from natural products. In the present study, an environmentally friendly extraction method based on DESs was established to extract bioactive phenolic acids from ALs. Diverse tailor-made solvents, including binary and ternary DESs, were explored for simultaneous extraction of four phenolic acids (3-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, and 4,5-di-O-caffeoylquinic acid) from AL. The results indicated that the ternary DES composed of a 2:1:2 molar ratio of choline chloride, malic acid, and urea showed enhanced extraction yields for phenolic acids compared with conventional organic solvents and other DESs. Subsequently, the extraction parameters for the four phenolic acids by selected tailor-made DESs, including liquid–solid ratios, water content (%) in the DESs, and extraction time, were optimized using response surface methodology and the optimal extraction conditions were: extraction time, 23.5 min; liquid–solid ratio, 57.5 mL/g (mL of DES/g dry weight of plant material); water content, 54%. The research indicated that DESs were efficient and sustainable green extraction solvents for extraction of bioactive phenolic acids from natural products. Compared to the conventional organic solvents, the DESs have a great potential as possible alternatives to those organic solvents in health-related areas such as food and pharmaceuticals.

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Environmentally-Friendly Extraction of Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja Leaves with Deep Eutectic Solvents and Evaluation of Their Antioxidant Activities

Cited by 54 publications

References 39 publications

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

Optimizing Ultrasound-Assisted Deep Eutectic Solvent Extraction of Bioactive Compounds from Chinese Wild Rice

Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) leaves using ethanol/salt aqueous two‐phase system coupled with ultrasonic

Green Extraction of Phenolic Acids from Artemisia argyi Leaves by Tailor-Made Ternary Deep Eutectic Solvents

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