This article proposes to develop a prediction model for traffic flow using kernel learning methods such as support vector machine (SVM) and multiple kernel learning (MKL). Traffic flow prediction is a dynamic problem owing to its complex nature of multicriteria and nonlinearity. Influential factors of traffic flow were firstly investigated; five-point scale and entropy methods were employed to transfer the qualitative factors into quantitative ones and rank these factors, respectively. Then, SVM and MKL-based prediction models were developed, with the influential factors and the traffic flow as the input and output variables. The prediction capability of MKL was compared with SVM through a case study. It is proved that both the SVM and MKL perform well in prediction with regard to the accuracy rate and efficiency, and MKL is more preferable with a higher accuracy rate when under proper parameters setting. Therefore, MKL can enhance the decision-making of traffic flow prediction. Copyright experiences, knowledge, expertise, and historical data, which could result in that the outcomes differ significantly from one person to another. This kind of limitation has weakened the accuracy and efficiency of solving the traffic flow problem. Meanwhile, traffic flow prediction is regarded as a dynamic problem incorporating various influential factors such as toll fee level and competition from other services. Hence, the selection, classification, and ranking of the variables should be concerned with. Additionally, the linear models in existing research studies cannot handle the problem with the nature of nonlinearity, and thus nonlinear models are needed to solve the problem. Furthermore, the qualitative factors should be dealt with and transferred into quantitative ones, so as to standardize all the factors. And because not all the variables are likely to be considered equally significant, scaling of data is needed, and data should be normalized before being employed for model training, after which advanced methods are required to be applied to give weight to these variables.Recently, various research works have been conducted to solve the traffic flow-relation problems, such as the traffic assignment models [2,3], development of traffic flow model and control [4][5][6][7], traffic signal coordination or optimization [8,9], and traffic flow prediction [10,11,13]. For the traffic assignment model, as the origin-destination demand is time varying at the peak periods of congestion, dynamic assignment models are needed [2]. Szeto et al. [3] propose a multiclass dynamic traffic assignment problem that considers the random evolution of traffic states. Previous research works of the prediction mainly concentrated on linear and nonlinear models. Wild [35] conducted studies on a forecasting method on the basis of classified historical patterns for traffic volume, where the developed forecasting procedure has some advantages compared with conventional approaches. While a combination approach based on principal component analysis and...