A 64 Mbit phase change memory chip is fabricated in 40 nm CMOS technology. An improved fully-differential sense amplifier with a bias voltage instead of the reference resistor branch is proposed to diminish the chip area. The transient response capability of the proposed sense amplifier is improved by removing the large parasitic capacitance of bit line in the feedback network. Smaller parasitic capacitance is also obtained by the separated programming and reading transmission gates to speed up the read operation. The hierarchical bit line architecture is used to reduce the length of bit line, and thus favorable read performance can be achieved.