Optimization of plant compositions of Trisattakula to maximize antibacterial activity and formulation development of film-forming polymeric solution containing Nigella sativa ethanolic extract

Monton, Chaowalit; Settharaksa, Sukanya; Suksaeree, Jirapornchai; Chankana, Natawat; Charoenchai, Laksana

doi:10.1007/s13596-021-00546-x

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…The retarded drug release was also observed in the thymoquinone release from FFPS formulation containing 5 % hypromellose E5 blended 0.5 % xanthan gum. It was released only 10 -15 % for 8 h of drug release study [33].…”

Section: Release Of Madecassoside and Asiaticoside From F11 And F12mentioning

confidence: 95%

Madecassoside and Asiaticoside-Loaded Film-Forming Polymeric Solutions Based on Hypromellose E5 and Eudragit® NE 30D

Suksaeree

Luprasong²,

Monton³

2022

Trends Sci

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The aim of this work was to prepare and evaluate the physicochemical properties of film-forming polymeric solutions containing madecassoside and asiaticoside. The stability and in vitro release were also investigated. Hypromellose E5 and Eudragit® NE 30D were used as film-forming agents. Glycerin was used as a plasticizer. Ethanol is used as a solvent and for shortening film drying. The best formulations composed of 5 % hypromellose E5, glycerin, ethanol, and Centella asiatica Cosmélène® in the ratio of 60:20:20:10 (Formulation 11) or 60:20:10:10 (Formulation 12) w/w. It could form a complete film after being applied to the skin within 10 - 15 min. The pH, viscosity, and spreadability values were 7.9, 23.7 cP, 25.1 g·cm2/s, for Formulation 11, and 7.9, 27.1 cP, and 23.4 g·cm2/s, for Formulation 12, respectively. They were stable for at least 6 months. Both formulations released only 13 % of madecassoside and 14 -15 % of asiaticoside to the phosphate buffer pH 7.4. In conclusion, the developed FFPS could be used as the delivery system for madecassoside and asiaticoside for skin application. HIGHLIGHTS The best film-forming polymeric solution formulation composed of 5 % hypromellose E5, glycerin, ethanol, and Centella asiatica Cosmélène® in the mass ratio of 60: 20: 20 (or 10): 10, respectively The developed film-forming polymeric solution was stable for at least six months at various temperatures The low content of madecassoside and asiaticoside released from the formulation was observed GRAPHICAL ABSTRACT

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Section: Release Of Madecassoside and Asiaticoside From F11 And F12mentioning

confidence: 95%

Madecassoside and Asiaticoside-Loaded Film-Forming Polymeric Solutions Based on Hypromellose E5 and Eudragit® NE 30D

Suksaeree

Luprasong²,

Monton³

2022

Trends Sci

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“…Bannai et al reported that hot methanol extract (70%) of black cumin seed healed infected wounds in rabbits by enhancing scab formation and granulation tissue formation in wound areas [ 222 ]. Film-forming polymeric solution containing black cumin extract can be used as an alternative antibacterial product for the treatment of skin infection caused by the two pathogens: S. aureus and S. epidermidis [ 223 ]. Future studies should focus to disentangle the mechanism of black cumin mediated wound healing.…”

Section: Benefits Of Black Cumin On Human Health and Disease Conditionsmentioning

confidence: 99%

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

et al. 2021

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Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The pleiotropic pharmacological effects of black cumin, and its main bioactive component thymoquinone (TQ), have been manifested by their ability to attenuate oxidative stress and inflammation, and to promote immunity, cell survival, and energy metabolism, which underlie diverse health benefits, including protection against metabolic, cardiovascular, digestive, hepatic, renal, respiratory, reproductive, and neurological disorders, cancer, and so on. Furthermore, black cumin acts as an antidote, mitigating various toxicities and drug-induced side effects. Despite significant advances in pharmacological benefits, this miracle herb and its active components are still far from their clinical application. This review begins with highlighting the research trends in black cumin and revisiting phytochemical profiles. Subsequently, pharmacological attributes and health benefits of black cumin and TQ are critically reviewed. We overview molecular pharmacology to gain insight into the underlying mechanism of health benefits. Issues related to pharmacokinetic herb–drug interactions, drug delivery, and safety are also addressed. Identifying knowledge gaps, our current effort will direct future research to advance potential applications of black cumin and TQ in health and diseases.

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“…For bacteria like Staphylococcus aureus and Staphylococcus epidermidis, it has shown low biofilm inhibition at the concentration of 22 µg/ml and 60 µg/ml, respectively (Yimer et al, 2019). Also, Monton et al (2021) exhibited the antibacterial property of N. sativa against skin infecting bacteria, i.e., S. aureus and S. epidermidis, hence it can be used in skin treatment. Recently, it has been reported that the bacterial strain Bacillus subtilis and Bacillus licheniformis were vulnerable to the phytochemicals of N. sativa seeds showing antibacterial activity (Habib et al, 2021).…”

Section: Antibacterial Activitymentioning

confidence: 99%

Potential activities of nanoparticles synthesized from Nigella sativa L. and its phytoconstituents: An overview

Balyan¹,

Shinde²,

Ali³

2021

jpps

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Optimization of plant compositions of Trisattakula to maximize antibacterial activity and formulation development of film-forming polymeric solution containing Nigella sativa ethanolic extract

Cited by 4 publications

References 32 publications

Madecassoside and Asiaticoside-Loaded Film-Forming Polymeric Solutions Based on Hypromellose E5 and Eudragit® NE 30D

Madecassoside and Asiaticoside-Loaded Film-Forming Polymeric Solutions Based on Hypromellose E5 and Eudragit® NE 30D

Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety

Potential activities of nanoparticles synthesized from Nigella sativa L. and its phytoconstituents: An overview

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