Optimization of poly(dimethylsiloxane) hollow prisms for optical sensing

Llobera, Andreu; Wilke, Ralph; Büttgenbach, S.

doi:10.1039/b416633g

Cited by 33 publications

(26 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, while conveniently delivering liquid samples to the refractometer. To date, optofluidic techniques have been employed to produce compact refractometers using diffraction gratings, 50,51 prisms, 52 and interferometers. 53–55 These designs enable highly sensitive and compact microfluidic refractometers.…”

Section: Introductionmentioning

confidence: 99%

A single-layer, planar, optofluidic Mach–Zehnder interferometer for label-free detection

et al. 2011

View full text Add to dashboard Cite

We have developed a planar, optofluidic Mach–Zehnder interferometer for the label-free detection of liquid samples. In contrast to most on-chip interferometers which require complex fabrication, our design was realized via a simple, single-layer soft lithography fabrication process. In addition, a single-wavelength laser source and a silicon photodetector were the only optical equipment used for data collection. The device was calibrated using published data for the refractive index of calcium chloride (CaCl2) in solution, and the biosensing capabilities of the device were tested by detecting bovine serum albumin (BSA). Our design enables a refractometer with a low limit of detection (1.24 × 10−4 refractive index units (RIU)), low variability (1 × 10−4 RIU), and high sensitivity (927.88 oscillations per RIU). This performance is comparable to state-of-the-art optofluidic refractometers that involve complex fabrication processes and/or expensive, bulky optics. The advantages of our device (i.e. simple fabrication process, straightforward optical equipment, low cost, and high detection sensitivity) make it a promising candidate for future mass-producible, inexpensive, highly sensitive, label-free optical detection systems.

show abstract

Section: Introductionmentioning

confidence: 99%

A single-layer, planar, optofluidic Mach–Zehnder interferometer for label-free detection

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Zhu et al (2006) improved collection efficiency by incorporating bare silicon detectors within the PDMS fluidic chip and reported a LoD for bovine serum albumin of 1 lg ml -1 with channels of 60-400 lm depth. Llobera and co-workers developed monolithically integrated hollow prism microchannels combined with optical components in a single-step PDMS microfabrication process (Llobera et al 2004(Llobera et al , 2005. The device, shown schematically in Fig.…”

Section: Absorption Detectionmentioning

confidence: 99%

Optofluidic integration for microanalysis

Hunt

Wilkinson

2007

Microfluid Nanofluid

130

View full text Add to dashboard Cite

This review describes recent research in the application of optical techniques to microfluidic systems for chemical and biochemical analysis. The ''lab-on-achip'' presents great benefits in terms of reagent and sample consumption, speed, precision, and automation of analysis, and thus cost and ease of use, resulting in rapidly escalating adoption of microfluidic approaches. The use of light for detection of particles and chemical species within these systems is widespread because of the sensitivity and specificity which can be achieved, and optical trapping, manipulation and sorting of particles show significant benefits in terms of discrimination and reconfigurability. Nonetheless, the full integration of optical functions within microfluidic chips is in its infancy, and this review aims to highlight approaches, which may contribute to further miniaturisation and integration.

show abstract

“…23,24 Additionally, in this work, the technological simplicity was kept to one photolithographic level. 23 Scanning electron microscope ͑SEM͒ pictures of the SU8 master ͑thickness of 120 m͒ are shown in Fig.…”

Section: Fabricationmentioning

confidence: 99%

A polymeric micro-optical interface for flow monitoring in biomicrofluidics

et al. 2010

View full text Add to dashboard Cite

We describe design and miniaturization of a polymeric optical interface for flow monitoring in biomicrofluidics applications based on polydimethylsiloxane technology, providing optical transparency and compatibility with biological tissues. Design and ray tracing simulation are presented as well as device realization and optical analysis of flow dynamics in microscopic blood vessels. Optics characterization of this polymeric microinterface in dynamic experimental conditions provides a proof of concept for the application of the device to two-phase flow monitoring in both in vitro experiments and in vivo microcirculation investigations. This technology supports the study of in vitro and in vivo microfluidic systems. It yields simultaneous optical measurements, allowing for continuous monitoring of flow. This development, integrating a well-known and widely used optical flow monitoring systems, provides a disposable interface between live mammalian tissues and microfluidic devices making them accessible to detection/processing technology, in support or replacing standard intravital microscopy.

show abstract

Optimization of poly(dimethylsiloxane) hollow prisms for optical sensing

Cited by 33 publications

References 12 publications

A single-layer, planar, optofluidic Mach–Zehnder interferometer for label-free detection

A single-layer, planar, optofluidic Mach–Zehnder interferometer for label-free detection

Optofluidic integration for microanalysis

A polymeric micro-optical interface for flow monitoring in biomicrofluidics

Contact Info

Product

Resources

About