The deposition of aerosol particles can significantly affect the surface transmittance of photovoltaic (PV) modules and thus reduce photoelectric efficiency. With the aid of the control variable method, orthogonal experimental design, and stepwise linear regression method, a numerical simulation study of the deposition process of aerosol particles on the surface of a PV module is carried out in this paper. The influence laws of inflow wind velocity (v), particle diameter (d), installation angle (𝜶), and particle concentration (c) on the deposition process of aerosol particles are analyzed, respectively. The deposition mechanism of aerosol particles on the surface of the PV module is disclosed, and the prediction model of deposition rate (n) is proposed. The results show that v, d, and c all positively affect n of the aerosol particles within the value ranges of each investigation variable in this study. 𝜶 positively affects n of the aerosol particles when v is less than 3.65 m s −1 . 𝜶 negatively affects the n of the aerosol particles when v is larger than 3.65 m s −1 . The prediction model could accurately predict the n of aerosol particles. This research has a theoretical guiding significance for the formulation process of cleaning strategies for the surface of PV modules.