Optimization of process conditions for chitosan-manuka honey film as wound contact layer for wound dressings

Many efforts have been made to develop modern wound dressings to overcome limitations of traditional ones. Smart nanocomposite hydrogels are appropriate candidates. In this work, a novel responsive nanocomposite hydrogel based on poly(vinyl alcohol)/chitosan/honey/clay was developed and evaluated as a novel wound dressing. The morphology and properties of synthesized nanocomposite hydrogels loaded with honey as a drug model were investigated. The exfoliated morphology of nanocomposite was confirmed by X-ray diffractometry. Swelling studies were performed at 20 and 37 8C at various pH. The results showed that swelling increased as a result of temperature rise and maximum swelling occurred at a pH of 2. In vitro release of honey was also studied at the same conditions. Corresponding results indicated faster honey release rate at higher pH values. MTT results exhibited no cytotoxicity in nanocomposite hydrogel system. Investigation of antibacterial activity revealed more than 99% antibacterial activity for proposed system. In vivo results confirmed the wound healing ability of developed system. Generally, appropriate properties of proposed system made it ideal in wound dressing applications.

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“…Therefore, based on pKa of carboxylic (4.7) and pKa of chitosan (6.5), the involving groups are

{NH}_{3}^{+}

and COOH (in pH range 1–3),

{NH}_{3}^{+}

and COO ‐ (in pH range 4–6.5) and NH 2 and COO ‐ (in pH range 7–13) . Sasikala et al . reported the effect of honey on swelling of hydrogels.…”

Section: Resultsmentioning

confidence: 88%

Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing

Noori

Kokabi

Hassan

2018

J of Applied Polymer Sci

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“…Hence, they are ideal dressings for superficial wound, epithelizing wound, and shallow wound [ 81 ]. The other interesting properties of the currently employed films include their high elasticity and flexibility resulting in their ability to be manipulated to any form with no need for additional tapping [ 82 , 83 ]. However, film dressings are not suitable for high exudate wounds because of their inability to absorb high amounts of biological fluids.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…El-kased et al studied the use of honey-based hydrogels made of chitosan and carbopol 934 for burn wounds and antibacterial action against Pseudomonas aeruginosa , Staphylococcus aureus , Streptococcus pyogenes and Klebsiella pneumonia [ 7 ]. The manuka honey, when mixed with chitosan to form hydrogel, showed a dose-dependent effect; when the concentration of honey is varied, the swelling of the gel is increased [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Chitosan/PVA Based Hydrogel Films Loaded with Honey for Wound Healing Application

Chopra

Bibi

Kumar³

et al. 2022

Gels

105

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In the present study, chitosan/polyvinyl alcohol (PVA)-based honey hydrogel films were developed for potential wound healing application. The hydrogel films were developed by a solvent-casting method and were evaluated in terms of thickness, weight variation, folding endurance, moisture content and moisture uptake. The water vapor transmission rate was found to range between 1650.50 ± 35.86 and 2698.65 ± 76.29 g/m2/day. The tensile strength and elongation at break were found to range between 4.74 ± 0.83 and 38.36 ± 5.39 N, and 30.58 ± 3.64 and 33.51 ± 2.47 mm, respectively, indicating significant mechanical properties of the films. SEM images indicated smooth surface morphology of the films. FTIR, DSC and in silico analysis were performed, which highlighted the docking energies of the protein–ligand complex and binding interactions such as hydrogen bonding, Pi–Pi bonding, and Pi–H bonding between the selected compounds and target proteins; hence, we concluded, with the three best molecules (lumichrome, galagin and chitosan), that there was wound healing potential. In vitro studies pointed toward a sustained release of honey from the films. The antimicrobial performance of the films was investigated against Staphylococcus aureus. Overall, the results signaled the potential application of chitosan/PVA based hydrogel films as wound dressings. Furthermore, in vivo experiments may be required to evaluate the clinical efficacy of honey-loaded chitosan/PVA hydrogel films in wound healing.

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Optimization of process conditions for chitosan-manuka honey film as wound contact layer for wound dressings

Cited by 22 publications

References 38 publications

Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing

Poly(vinyl alcohol)/chitosan/honey/clay responsive nanocomposite hydrogel wound dressing

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Preparation and Evaluation of Chitosan/PVA Based Hydrogel Films Loaded with Honey for Wound Healing Application

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