2020
DOI: 10.1016/j.heliyon.2020.e05103
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Optimization of process variables for acetoin production in a bioreactor using Taguchi orthogonal array design

Abstract: Microbial production of acetoin is eco-friendly and inexpensive when compared with its synthetic methods of production. In the present findings, bioproduction of acetoin in a typical bioreactor was discussed with a view to ascertain the seemingly comparative advantage of bioreactor system over shake flask, and more importantly, to confirm that corn steep liquor can indeed adequately be used as a replacement for other organic nitrogen sources. Taguchi design was statistically used to optimized the fermentation … Show more

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Cited by 31 publications
(14 citation statements)
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“…The ratio of the mean of squared deviations to the mean of squared errors ratio (F-value) shows the relative significance of each parameter of the experiment. In this research, since the degree of freedom of error was zero due to the selection of an over-fitted design [ 13 ], the contribution of each factor on the properties of AASC (responses) was calculated based on Equation (11) [ 70 ]. …”
Section: Methodsmentioning
confidence: 99%
“…The ratio of the mean of squared deviations to the mean of squared errors ratio (F-value) shows the relative significance of each parameter of the experiment. In this research, since the degree of freedom of error was zero due to the selection of an over-fitted design [ 13 ], the contribution of each factor on the properties of AASC (responses) was calculated based on Equation (11) [ 70 ]. …”
Section: Methodsmentioning
confidence: 99%
“…Therefore, the percentage contribution of each examined parameter was calculated directly by computing the ratio of the sum of squares of each parameter (Equation [4]) to the total sum of squares of all examined parameters (Equation [5]) based on Equation (6). 60,63…”
Section: Methodsmentioning
confidence: 99%
“…As the DOF of error was zero due to the selection of over‐fitted design, the F ‐value, which is the ratio of the mean of squared deviations to the mean of squared errors, 60 could not be computed. Therefore, the percentage contribution of each examined parameter was calculated directly by computing the ratio of the sum of squares of each parameter (Equation []) to the total sum of squares of all examined parameters (Equation []) based on Equation () 60,63 SSi=false∑j=1nnS/NitalicjiS/NMean SSt=false∑i=1n()S/NiS/NMean2 PCi=SSiSSt×100 …”
Section: Methodsmentioning
confidence: 99%
“…Several factors augment the complexity of the design, including the curing conditions, composition of the raw materials, soluble silicate content, and the activation solution and its alkalinity. As such, mixes become cumbersome and practically inconclusive without an excessive trial-and-error analysis [19]; thus, extensive experiments are needed to deduce the optimum mix while satisfying the desired performance [30]. Optimization techniques can be employed based on the desired performances or criteria to overcome such complex processes and excessive trial mixes and deduce the desired optimum mix using a limited number of experiments [31].…”
Section: Introductionmentioning
confidence: 99%